Pharmacokinetic Modelling of Lamotrigine from
Plasma Concentrations in Healthy Volunteers |
| Ilbeyi Agabeyoglu*, Tuba Incecayir |
| Dept.Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, TURKEY |
| *Corresponding author: |
Prof.Dr.Ilbeyi Agabeyoglu,
Gazi Univ. Ecz. Fak.
Etiler 06330 Ankara/TURKEY,
Tel: +90 (532) 262 99 39,
Fax: +90 (312)
212 79 58,
E-mail: ilbeyi@tr.net |
|
| Received December 06, 2009; Accepted December 28, 2009; Published
December 28, 2009 |
Citation: Agabeyoglu I, Incecayir T (2009) Pharmacokinetic Modelling of Lamotrigine from Plasma Concentrations in Healthy Volunteers. J Bioanal Biomed 1: 041-045. doi:10.4172/1948-593X.1000009 |
Copyright: © 2009 Agabeyoglu I, et al. This is an open-access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited. |
| Abstract |
The pharmacokinetics of the antiepileptic agent
lamotrigine (CAS 84057-84-1) was investigated after
single oral doses in 14 healthy volunteers. After the administration
of single oral doses of 2x100 mg lamotrigine
chewable/soluble tablets to healthy volunteers, blood
samples were collected for the next 96 h. The pharmacokinetic
modelling of lamotrigine showed that the drug
exhibited two compartment open model with regard to the
goodness of fits, Residual Sum of Squares (RSS), Akaike’s
Information Criteria (AIC), Schwartz Criteria (SC), standard
deviation of the regression (Sr), and determination
coefficient (r2). The time-concentration curves showed a
mean time to reach peak plasma concentration, Cmax (tmax)
of 2.0 h. The pharmacokinetic parameters were calculated
based on the plasma curves. Area under the curve of concentration
versus time from zero to infinity (  ), systemic
clearance (Cl), apparent volume of distribution
(Vdarea), apparent volume of distribution at steady state
(Vdss), apparent volume of distribution for I.V. (Vdext), and
mean residence time (MRT) were found to be 128±31 μg.h/
mL, 1.63±0.39 L/h, 88.5±28.6 L, 83.2±23.6 L, 93.2±35.6
L, and 62.6±13.7 h (mean±SD), respectively. Compartmental
analysis demonstrated that oral lamotrigine tablets
obey two compartment open model with rapid absorption
and a relatively long half life. |
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