In-Vitro Release and Pharmacokinetics of Anti-tubercle
Drug Ethionamide in Healthy Male Subjects |
Mahmood Ahmad *, Asad Ullah Madni, Muhammad Usman |
Department of Pharmacy, the Islamia University of Bahawalpur, Pakistan-63100 |
| *Corresponding author: |
Dr.Mahmood Ahmad,
Department of Pharmacy,
the Islamia University of Bahawalpur,
Pakistan-63100,
E-mail: ma786_786@yahoo.com |
|
| Received December 26, 2009; Accepted December 30, 2009; Published
December 30, 2009 |
Citation: Ahmad M, Madni AU, Usman M (2009) In-Vitro Release and Pharmacokinetics of Anti-tubercle Drug Ethionamide in Healthy Male Subjects. J Bioanal Biomed 1: 046-049. doi:10.4172/1948-593X.1000010 |
Copyright: © 2009 Ahmad M, et al. This is an open-access article distributed
under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited. |
| Abstract |
| The aim of study was to assess the pharmacokinetics of
ethionamide in the local population of healthy human subjects.
Serum samples were taken from each of the selected
subject at different time intervals. These samples were
analyzed by using High Performance Liquid Chromatography
consisting of reverse phase C18 column, UV detector
set at 291nm. The mobile phase was consisted of 0.02
M disodium hydrogen phosphate and acetonitrile (75:25)
and delivered at a rate of 1.5ml/min. The value of Cmax was found to be 1.941 ± 1.487 μg/ml (mean ± SEM) and
Tmax was 1.75 ± 1.487 hours (mean ± SEM). The area under
the curve (AUC) was 8.745 ± 0.536 (mean ± SEM).
The elimination half life (t½) was found out as 1.995 ±
1.157 hours (mean ± SEM). The total body clearance (Cl)
was determined as 32.591 ± 0.298 ml/hr/kg (mean ± SEM).
It was concluded that ethionamide (Ethomid® Schazoo-
Lahore, Pakistan) found in consistent with the values reported
in the available literature. The study will be beneficial
and valuable in designing dosage regimen for the
patients on ethionamide therapy and can be utilized as
guideline in accessing the bioavailability and pharmacokinetics
parameters in clinical situations. |
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