Role of Cation-π Interactions in the
Structural Stability of Bacterial Exotoxins |
| Anand Anbarasu* and P.S. Shrivaishnavi |
| Bioinformatics Division, School of Biosciences & Technology, VIT University, Vellore-632014, India |
| *Corresponding author: |
Dr. Anand Anbarasu, Bioinformatics Division,
School of Biosciences & Technology,
VIT University, Vellore-632014,
India,
Tel : +91-416-2202556/2574/2608,
Fax : +91-416-2243092,
E-mail : aanand@vit.ac.in |
|
| Received December 20, 2009; Accepted December 28, 2009; Published December 29, 2009 |
Citation: Anbarasu A, Shrivaishnavi PS (2009) Role of Cation-p Interactions in the Structural Stability of Bacterial Exotoxins. J Microbial Biochem Technol 1: 022-029. doi:10.4172/1948-5948.1000005 |
Copyright:© 2009 Anbarasu A, et al. This is an open-access article
distributed under the terms of the Creative Commons Attribution
License,which permits unrestricted use, distribution, and reproduction
in any medium, provided the original author and source are credited. |
| Abstract |
Bacterial exotoxins secreted by bacteria can cause damage
to the host by destroying cells or disrupting normal
cellular metabolism. They may exert their effect locally
or produce systemic effects. We have presented the results
observed with cation-π interactions in bacterial exotoxins
in relation to environmental preferences like secondary
structure, solvent accessibility, and stabilization
centers. Arg have a higher occurrence than Lys in the cationic
group and Tyr contributes in higher numbers than
Phe and Trp in π group. Our results might be useful for
understanding the stability patterns of exotoxins in bacteria. |
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