Analysis of Binding Properties of Phosphoinositide
3-kinase Through In silico Molecular Docking |
| P. Daisy*, R. Sasikala, A. Ambikar |
| Bioinformatics centre (BIF), Department of Biotechnology & Bioinformatics,
Holy Cross College, Tepakulam, Tiruchirapalli-620002, India |
| *Corresponding author: |
Dr. P. Daisy, Co-coordinator, Bioinformatics centre (BIF), Department of Biotechnology & Bioinformatics, Holy Cross College, Tepakulam, Tiruchirapalli- 620002,
India,
Phone : 0431-2700637,
Fax : 0431-2713312,
E-mail: daisylesslie@gmail.com |
|
| Received May 12, 2009; Accepted June 18, 2009; Published June 18, 2009 |
Citation: Daisy P, Sasikala R, Ambika A (2009) Analysis of Binding Properties of Phosphoinositide 3-kinase Through In
silico Molecular Docking. J Proteomics Bioinform 2: 274-284. doi:10.4172/jpb.1000086 |
Copyright: ©2009 Daisy P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author
and source are credited. |
| Abstract |
Phosphoinositide 3-kinases (PI3-kinases) are increasingly considered to have a key role in intracellular signal
transduction in health and disease. Particularly the enzymes plays vital role in wide range of cancer such as
breast, ovarian, myeloid leukemia, prostate, Small Cell Lung cancer (SCLC) etc., Compounds such as Wortmannin,
LYS2002 are the inhibitors of PI3-kinases but these compounds shown adverse side effects . Hence five natural
flavanoids having inhibitory effects on PI3-kinase namely Andrographolide, Kaempferol, Luteolin, Quercetin
and Gingerol were taken for in silico prediction of binding affinities of the protein PI3- kinase. Our reports can be
used to develop new inhibitors with better binding affinities towards the protein PI3-kinase protein. For the
binding analysis the catalytic subunit of the protein PI-3 Kinase p110α was taken for the study as it considered
being a potential target in cancer treatment. |
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