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Methylation Level of ASC/TMS1 and MYD88 Genes in Healthy Larynx and Laryngeal Carcinoma Tissue
Background: There are no biomarkers for diagnosis, prognosis and treatment of patients with laryngeal carcinoma. Methylation changes of ASC/TMS1 and MYD88 genes, in healthy and cancer tissue, might be related with development and progression of cancer. The study explored is there a difference in gene’s methylation in healt.. Read More
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Coronary Artery Disease (CAD) is the leading cause of death in developed countries. Studies have indicated that ischemic tissues may release exosome-carried microRNAs (miRNAs) into circulation. miRNAs are a class of small, endogenous, noncoding RNAs that regulate the expression of multiple target genes at the posttranscriptional.. Read More
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High Expression of AFF1 Associate with Poor Prognosis for Patients with Acute Myeloid Leukemia
Background: AFF family genes (AFFs) are closely related to the occurrence, development and prognosis of leukemia, but its relationship with Acute Myeloid Leukemia (AML) is not clear. This study aims to explore the relationship between AFFs and the prognosis of AML through bioinformatics methods and clinical data. Methods: The e.. Read More
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Primary Sebaceous Carcinoma of Esophagus
Background: Sebaceous Carcinoma (SC) is an uncommon neoplasm that usually occur in the skin of head and neck region with a predilection of periocular sites. This tumor is thought to arise from sebaceous glands in the skin and thus may arise anywhere on the body where these glands exist. However, the non-cutaneous SC in where the.. Read More
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Background: Breast cancer subtypes were designed not only to guide decision regarding targeted therapy but also to evaluate the prognosis of the disease together with other pathological factors. This study aimed at determining the distribution of breast cancer molecular subtypes, and their association with clinical and pathologi.. Read More
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Background: We explored the effects of INF-γ-modified Bone Marrow Mesenchymal Stem Cells (BMSCs) on the distribution and inhibition of tumour tissues. Methodology: BALB/c mouse BMSCs were cultured, isolated and identified by flow cytometry. Constructed a lent viral expression vector for the INF-γ gene; BMSCs transfect.. Read More
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Hymenolepis diminuta Infection in an Adult’s Lung: A Rare Case Report
Hymenolepis diminuta is a cosmopolitan parasite of rats and mice which is very rare in humans but has been reported from various areas of the world. We report a human case of Hymenolepis diminuta pulmonary infection in Jiangsu Province, China and it has never been reported in patient’s Lung before. In the process of the di.. Read More
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Autoimmune Hepatitis (AIH), characterized with excessive production of proinflammatory cytokines and progressive damage of hepatocytes, is an inflammatory disease of unclear pathogenesis. AIH affects all age group and occurs mainly in women. Pyroptosis is a novel programmed cell death featured with a distinct morphology associat.. Read More
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Background: Severe trauma could induce sepsis due to the loss of control of the infection, which may eventually lead to death. Accurate and timely diagnosis of sepsis with severe trauma remains challenging both for clinician and laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis. We therefore c.. Read More
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Dynamical Patterns in Gene Expression Profile After Influenza A Virus Injection
Background: Finding the underlying gene regulatory mechanisms for complex diseases is essential for systems biology. The dynamic mode decomposition is adopted in this article to unveil the coherent dynamical patterns that correspond to viral recognition receptors in time-course gene expression profiles after injection of the Inf.. Read More
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Host Specific Eimeria Genus Diagnosis and QPCR Development in Sheeps and Goats
Coccidiosis of sheep and goats is caused by protozoa in the genus Eimeria. These protozoa mainly affect young animals, causing a decrease in production and consequent economic losses. Routine diagnosis is made through morphological observation of the oocysts, which has several limitations. The objective of the present study was .. Read More
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Fine Needle Aspiration Cytology of the thyroid gland has proven to be effective in the categorization of thyroid lesions into benign, atypical, suspicious and malignant categories. However only scanty data has been available regarding the prevalence of thyroid lesions in Uganda. This study aimed at classifying thyroid lesions cy.. Read More
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Acinic Cell Carcinoma of the breast (ACC) is a very rare subtype of breast cancer, being of bland cellular morphology, but having a triple-negative phenotype. Usually, it was thought to be indolent, but a few cases have been reported highly aggressive. The molecular studies showed similar features in diagnosing to the Triple-Neg.. Read More
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Developing prognostic markers can aid in clinical decision making. Peripheral Blood (PB) testing is a simple and basic test that can be performed at any facility. Changes in blood cell morphology as prognostic indicators of coronavirus infection (COVID-19) have been studied using an automated image recognition system based on Co.. Read More
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A Comprehensive Analysis of the Expression and Prognosis of STATs in Human Breast Invasive Carcinoma
Background: Multiple cancer types are associated with the Signal Transducer and Activator of Transcription (STAT) family of proteins. The expression and prognostic value of STATs in Breast Invasive Carcinoma (BRCA) remain unclear. Methods: Herein we investigated the clinical data onto 1,222 patients with BRCA based on the Cancer.. Read More
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Detrimental Role of ‘Decoy’ Constituents in Tuberculosis Vaccination
Infection with Mycobacterium tuberculosis (Mtb) is being continually transmitted by cases with active pulmonary Tuberculosis (TB), prior to their late detection. Consequently, TB remains a major global health problem, despite its effective, though protracted, sterilizing chemotherapy. The widely used vaccination with attenuated .. Read More
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This paper analyzes the behavior of Alzheimer’s disease simulations in an artificial neural network and based on the results proposes alternative possible diagnoses for Alzheimer’s disease. This is one of the most common fatal diseases, increasing in severity over time. Despite its high prevalence and thousands of ye.. Read More
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Giant Cell (Temporal) Arteritis: The Rate and Clinical Predictors of Histopathological Diagnosis
Purpose: To determine the rate of histopathological diagnosis by Temporal Artery Biopsy (TAB) and the predictive clinical features of TAB positivity in patients with Giant Cell Arteritis (GCA). Methods: The records of patients who underwent TAB with pre diagnosis of GCA between January 2006 and May 2020 were retrospectively rev.. Read More
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Development of a Modified Extended Model Based Fault Detection and Diagnosis Approach
A supervisory system for space missions is critical due to the high risk of missions, the costs and the impossibility of adding redundancy. The model based fault detection approaches are of interest due to their highly responsive speed, robustness against disturbances and uncertainties and accuracy. Conventional model based meth.. Read More
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A Comparative Study of the Fixative Properties of Honey and Formalin
Before a routine histological or cytological examination, tissues are fixed, maintained, and guarded against putrefaction and autolysis. The fixative is most frequently used to fix tissues in formalin. Because of its toxicity using formalin poses health risks, according to the Occupational Safety and Health Administration (OSHA).. Read More
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