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Background: High levels of adhesion molecules are known to result in inflammation of the vascular cells through endothelial dysfunction and thus atherogenesis. To this end, this trial was performed to investigate whether a cause of the accelerated atherogenesis in cases with non-alcholic fatty liver disease (NAFLD) was the incre.. Read More
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Background: Vitamin D deficiency is a widely discussed topic in medicine. However, the phenomenon that postmenopausal women have higher 25(OH)D3 concentrations compared to men or younger women is rarely described in the scientific literature. Therefore the objective was to investigate this phenomenon in a representative populati.. Read More
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The purine nucleoside adenosine has the critical autacoid function of directly linking cellular excitability to energy availability. The mechanism is activated whenever the rate of adenosine triphosphate (ATP) utilization exceeds the rate of synthesis. In CNS neurons, adenosine is produced by the rapid intracellular hydrolysis o.. Read More
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Postmenopausal osteoporosis is a high turnover type of osteoporosis induced by estrogen deficiency following menopause. In this type of osteoporosis, the osteoblastic activity is known to be elevated even though bone resorption by osteoclasts eventually exceeds bone formation by osteoblasts, resulting in the deterioration of the.. Read More
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Bradykinin Signal Pathways Modulate Neurohypophyseal Hormones Secretion
Afferent renal nerves stimulate vasopressin (VP) secretion by activation of VPergic neurons of supraoptic (SON) and paraventricular nuclei (PVN). Therefore, intrarenal infusion of bradykinin (BK), which excites afferent renal nerves, increases VP release. However, BK is also a potent intrarenal vasodilatator hence BK may modulat.. Read More
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Primitive stem cells have been discovered within the blood of adult mammals such as rodents, porcines, and humans. The current study addressed the issue of primitive stem cells in the blood of adult equines. Blood withdrawal by venipuncture from adult equines was performed following the guidelines of Fort Valley State University.. Read More
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Drug-induced hypothyroidism has been often observed with the use of lithium in patients with mental disorders. However, atypical antipsychotic medications, especially those with serotonin 2c (5HT2c) blockade like dibenzodiazepines have not been examined for their association with the occurrence of subclinical hypothyroidism. Aty.. Read More
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Background: Renal α1B-adrenoreceptors (α1-ARs) contributes to the pathogenesis of hypertension in spontaneously hypertensive rats (SHR). The present study examined the role of α1B-ARs in renal hemodynamic and tubular functions in SHR subjected to high-salt diet (SHRHNa) for 6 weeks. Methods: Renal cortical vaso.. Read More
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Reviews: Serum Anticholinergic Activity: A Biomarker for Rapid Progression of Alzheimer's Disease
We have previously reported the possibilities that anticholinergic activity (AA) appeared endogenously in Alzheimer’s disease (AD) and accelerated AD pathology. In this article we reviewed the reasons why AA endogenously appeared in AD and accelerated AD pathology and that the serum anticholi.. Read More
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The functional impairment of bone marrow derived endothelial progenitor cells remains an important barrier for cardiac cell-based therapies. Our aim was to create a relevant swine model of chronic ischemia and document its effect on bone derived progenitor cells. We hypothesized that bone marrow de.. Read More
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Stem Cell Therapy for Endothelial Dysfunction in the Coronary Circulation
The endothelium is increasingly recognized as serving a critical role in maintaining circulatory homeostasis. Endothelial dysfunction is evidenced as an attenuation or exaggeration of the normal dynamic vasomotor range. Circulating endothelial progenitor cells (EPCs) are responsible for the endothe.. Read More
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Male Breast Cancer in Fiji - A Descriptive Study
Objective: To describe the trends in epidemiology of adult male breast cancer in Fiji and compare with international trends Study design: Population based descriptive study of retrospective data over an 11 year period. Methodology: Secondary data from Fiji’s cancer card registry was analysed from 2000-2010 to describe tren.. Read More
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