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Objective(s): The present study was designed to provide additional information on the levels of cytokine responses, endothelial injury, and oxidative stress responses during prolonged cigarette smoking using the serum levels of interleukin-1β, IL-10, CRP, liver enzymes (aspartate transaminase, alanine transaminase, alkaline.. Read More
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Although recent advances have improved the management of multiple myeloma, it remains an incurable malignancy. We now demonstrate that anti-CD138 genetically fused to interferon alpha14 (IFNα14) synergizes with the approved therapeutic lenalidomide in arresting the proliferation of the human multiple myeloma cell line NCIH9.. Read More
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Objective: Increasing evidence in both experimental and clinical studies suggests that there is a close link between hyperglycemia, oxidative stress, and diabetic complications. Resveratrol a polyphenolic compound found in various natural food products. Methods: Four groups male adult albino rats were used in this study: Negati.. Read More
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Neuroprotective Effects of Selective Serotonin Reuptake Inhibitors
Serotonin reuptake inhibitors (SSRIs) have been suggested to have a neuroprotective effect. This claim is is largely clinical and not previously supported by evidence based data. This area of neuroscience has not been well studied at the cellular level. This study offers a three part laboratory examination of the effect of SSRIs.. Read More
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Bovine herpesvirus 1 (BoHV-1) infection extensively modulates host-cell gene expressions. To further understandings of BoHV-1 pathogenesis, Madin-Darby bovine kidney cells were infected, and RT-qPCR expression analyses were performed. Apart from classical immune genes (e.g. PKR, Mx1, IRF7, CCR4, TXNIP), EGR3, IFITM3, and ISG15 p.. Read More
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The pathogenic mechanism of the infectious salmon anemia virus (ISAv) remains unknown. One methodological approach for solving this unknown is to understand the roles of each viral component separately. Therefore, the present study evaluated the viral nucleoprotein (NP) of ISAv to establish effects to reactive oxygen species (RO.. Read More
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Background: Dendritic cell (DC) activation induces expression of co-stimulatory surface molecules, as well as migration into secondary lymphoid organs, where they activate naïve T cells. A family of plant derivatives, eremophilanetype petasite sesquiterpenes can regulate the immune system through DC targeting due to their a.. Read More
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Re-thinking Vaccinology: “Act Universally, Think NK Cells”?
Traditional and modern vaccines that are currently licensed for commercial use have proven safe and effective in fighting several infectious diseases; they are unquestionably among the most efficient tools for promoting individual, public and global health. However, the vaccine field is still facing important shortcomings in tha.. Read More
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Molecular Mechanisms Involved in the Immune Control of the Malignant Disease Process
In order to control Cancer effectively, it is essential to define the role of the host immune system in responding to the presence of growing tumour. For the most part the immune system is virtually oblivious to the existence of malignant cells developing within an organ. Understanding how immune reactivity can be activated to r.. Read More
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The HLA Profile of Ethiopian Discordant and Concordant Couples: In Comparison with AIDS Patients
In order to analyze the effect of host HLA types on resistance or susceptibility to HIV infection and to study the HLA profile Of Ethiopian HIV/AIDS subjects DNA based HLA typing was carried out on 239 discordant, concordant couples and full blown HIV AIDS subjects. Our study showed that there was a clear difference between disc.. Read More
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Obesity is considered a main factor contributing in diabetes mellitus development and a predictor of CV disease and events. Based on the Adult Treatment Panel-III criteria subjects with established obesity and co-existing other metabolic abnormalities including dyslipidaemia, insulin resistance (IR), increased fasting glucose an.. Read More
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The aim of this study was to compare the method agreement between the Pneumococcal 23vELISA (VaccZyme™, the Binding Site) and 13-valent serotype-specific multiplex assay in evaluating vaccination responses to Pneumovax® in patients with suspected antibody deficiency. Diagnostic accuracy in antibody deficiencies is im.. Read More
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Analysis of T cell subpopulations in discordant couples showed no activation of a specific marker between discordant positives and negatives and the expression of T cell subpopulations was comparable. The expression of activation markers was in significantly (P<0.05) higher in concordant couples compared with discordant posit.. Read More
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Host-oriented Inherent Measures and Eukaryotic Parasite Countermeasures
The recognition and elimination of eukaryotic parasites appear to be a hardwired prerequisite for host survival. However, eukaryotic parasites, such as Toxoplasma gondii, Leishmania sp., Trypanosoma cruzi, Giardia sp., and Schistosoma sp. employ the innate system of the host for their growth, replication, and continuation of the.. Read More
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Immunogenicity and Efficacy of Coxsackievirus A16 Vaccine Candidate Formulations in a Mouse Model
Besides enterovirus 71 (EV71), Coxsackie virus A16 (CVA16) is a major etiologic agent of hand, foot and mouth disease (HFMD), causing infections in millions of children under 5 years of age each year. The progress made in the development of inactivated EV71 vaccines encourages research aiming at developing a CVA16 vaccine for be.. Read More
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Objective(s): The present study was designed to provide additional information on some hematological and biochemical changes associated with blood transfusion in sickle cell anemia (SCA) patients.Materials and methods: A total of 86 subjects (aged between 20 and 40 years) were randomly studied. Among these were 30 multi-transfus.. Read More
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Marvelon Induced Deep Venous Thrombosis: Case Report
We evaluate a case report of Marvelon caused lower extremity deep venous thrombosis in order to provide reference for safety use of oral contraceptives... Read More
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Prothymosin alpha (ProTα) and thymosin beta (Tβ), members of the thymosin family, consist of a series of highly conserved peptides capable of stimulating immune responses in different species. Our recently published report discussed an issue of the conserved roles of ProTα b and Tβ-like (Tβ-l) in common .. Read More
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The Role of Microparticles in Rheumatic Diseases and their Potentials as Therapeutic Tools
Microparticles (MPs, also known as microvesicules or ectosomes) are heterogeneous subcellular vesicular particles (0.1-1.0 nm in diameter) released constitutively from cells and platelets undergoing cell activation or cell death by blebbing or shedding. Platelet MPs are usually the most abundant type in blood. The presence of ba.. Read More
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