Scot C Remick
FACP Professor of Medicine
Director, Mary Babb Randolph Cancer Center
Robert C. Byrd Health Sciences Center
West Virginia University
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Impact Factor: 0.5*
Index Copernicus Value: 4.96
Blood Disorders & Transfusion Journal is a peer reviewed and open access journal aimed to publish most interesting and complete reliable source of information on current development and advanced research findings in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide.
Journal of Blood Disorders & Transfusion is an academic journal that focuses on all aspects of molecular genetics, pathophysiology and epidemiology as well as prevention, diagnosis, and management of blood disorders with current state of research in the field of transfusion medicine, hematology, hemato-oncology, pediatric hematology, laboratory hematology, Neuropathy, Blood Donors, Thalassemia, Bone Marrow Transplantation, Anti-HBc, Haemodilution, plasma, hemodialysis, Blood Stem Cell, blood disorders, Rh factor, blood cancer, Platelet disorders, Hemolytic Anemia etc.
The journal is using Editorial Manager System for quality in review process. This is an online manuscript submission, review and tracking systems used by most of the best open access journals. Review process is performed by the editorial board members of the Journal of Blood Disorders & Transfusion or outside experts; at least two independent reviewer’s approval followed by the editor approval is required for acceptance of any citable manuscript.
Blood group is a classification of blood based on the presence or absence of inherited antigenic substances on the surface of red blood cells (RBCs). Blood group is also called as blood type. Genetic makeover is bought by respective parents determining which antigen is present on the red blood cells. This helps to find out the father of a child.
Haemostasis is a process of formation of clot bleeding to stop bleeding that is the first stage of wound healing. Hemostasis occurs when blood is present outside of the body or blood vessels. Hemostasis has three major steps: 1) vasoconstriction, 2) temporary blockage of a break by a platelet plug, and 3) blood coagulation, or formation of a fibrin clot.
Sickle cell disease is caused by a genetic abnormality in the gene for hemoglobin, which results in the production of sickle hemoglobin. When oxygen is released from sickle hemoglobin, it sticks together and forms long rods, which damage and change the shape of the red blood cell. The sickle red blood cells cause the symptoms of sickle cell disease.
Clotting of the blood in a part of the circulatory system is called thrombosis which leads to obstructing the flow of blood through the circulatory system. Thrombus is significantly large enough to reduce the blood flow to a tissue, hypoxia (oxygen deprivation) can occur and metabolic products such as lactic acid can accumulate. Thromboembolism is the combination of thrombosis and its main complication.
Lymphocytes are an important part of the immune system. A count significantly higher than 3,000 lymphocytes in a microliter of blood is generally considered to be lymphocytosis in adults. In children, the threshold for lymphocytosis varies with age, but may be as high as 7,000 to 9,000 lymphocytes per microliter. Lymphocytosis or a high lymphocyte count, is an increase in white blood cells called lymphocytes.
Auto immune disorder is a disorder occurs when antibodies attack the same tissues of the body believing it as antigens. Symptoms depend on the disorder occurred and at the site of the body affected. Immunosuppresants are used as treatment of auto immune disorder.
Lupus is a chronic, autoimmune disorder. It is affected by damaging body parts like skin, joints and other organs of the body. It is affected by treating self-tissues as foreign invaders causing inflammation, pain and damage in various parts of the body.
SLE is also known as discoid lupus or disseminated lupus erythematous. An autoimmune disease occurs when the immune system attacks its own body. Symptoms can vary and can change over time. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system.
Lymphoma is a form of cancer that affects the immune system specifically effects lymphocytes which are a type of white blood cell. There are two broad types of lymphoma and many subtypes. The two types of lymphoma are described as: Hodgkin's or non-Hodgkin's.
Red blood cells are red only because they contain a protein chemical called hemoglobin which is bright red in color. Hemoglobin contains the element Iron, making it an excellent vehicle for transporting oxygen and carbon dioxide. As blood passes through the lungs, oxygen molecules attach to the hemoglobin.
White blood cells (leukocytes) are an important part of the body’s defense against infectious organisms and foreign substances. To defend the body adequately, a sufficient number of white blood cells must receive a message that an infectious organism or foreign substance has invaded the body, get to where they are needed, and then kill and digest the harmful organism or substance.
Antiphospholipid syndrome (APS) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. Characteristic laboratory abnormalities in APS include persistently elevated levels of antibodies directed against membrane anionic phospholipids (ie, anticardiolipin [aCL] antibody, antiphosphatidylserine) or their associated plasma proteins, predominantly beta-2 glycoprotein I (apolipoprotein H); or evidence of a circulating anticoagulant.
Leukopenia is a reduction in the circulating WBC count to < 4000/μL. It is usually characterized by a reduced number of circulating neutrophils, although a reduced number of lymphocytes, monocytes, eosinophils, or basophils may also contribute which leads to great decrease in immune function.
Vasculitis is a general term that refers to inflammation of blood vessels. When blood vessels become inflamed, they may become weakened, stretch, and either increase in size or become narrow, even to the point of closing entirely. Many forms of vasculitis may be restricted to particular organs and sometimes may affect many organ systems at the same time. Some of these generalized forms may be quite mild and may not require treatment.
Blood cancers affect the production and function of your blood cells. Most of these cancers start in your bone marrow where blood is produced. Stem cells in bone marrow mature and develop into three types of blood cells: red blood cells, white blood cells, or platelets. In most blood cancers, the normal blood cell development process is interrupted by uncontrolled growth of an abnormal type of blood cell. These abnormal blood cells, or cancerous cells, prevent blood from performing many of its functions, like fighting off infections or preventing serious bleeding.
Autoimmune hemolytic anemia is a group of disorders characterized by a malfunction of the immune system that produces autoantibodies, which attack red blood cells as if they were substances foreign to the body. Autoimmune hemolytic anemia is an uncommon group of disorders that can occur at any age. These disorders affect women more often than men. Autoimmune hemolytic anemia can also be caused by or occur with another disorder, such as systemic lupus erythematosus (lupus), and rarely it follows the use of certain drugs, such as penicillin.
Anemia develops when deficiency of red cells or of haemoglobin in the blood occurs. Hemoglobin is a main part of red blood cells and binds oxygen. Certain forms of anemia are hereditary and infants may be affected from the time of birth. Women in the childbearing years are particularly susceptible to iron-deficiency anemia because of the blood loss from menstruation and the increased blood supply demands during pregnancy. There are many types of anemia. All are very different in their causes and treatments.
Increase in the number of eosinophils in the bloodis called Eosinophilia and occurs in response to some allergens, drugs, and parasites, and in some types of leukaemia. Peripheral blood eosinophil count is > 500/ μl. Eosinophilia can be idiopathic, the disease may be controlled with corticosteroids.
Lymphocytosis is a relatively common finding on routine FBCs in younger patients it is usually transient and reactive and in older patients a persistent lymphocytosis may be due to an underlying lymphoid disorder such as CLL or lymphoma where as in normal people blood lymphocytes are made of T cells (80%) and B cells (20%). Non-malignant transient causes include viral infections such as infectious mononucleosis, CMV, HIV and hepatitis; chronic infection with brucellosis, tuberculosis and syphilis, splenectomy have a persistent lymphocytosis, chronic lymphoproliferative disorders will cause a persistent of more than 3 months.
Juvenile myelomonocytic leukemia is found in children as an aggressive pediatric myelodysplastic syndrome (MDS)/myeloproliferative disorder (MPD) symptomized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny . JMML constitutes approximately 30% of childhood cases of myelodysplastic syndrome and 2% of leukemia. JMML and CMML have a high frequency of mutations affecting the RAS signaling pathway and show hypersensitivity to stimulation with GM-CSF, which causes STAT5 hyperphosphorylation.
Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4-5% of total body neutrophil stores. Most of the neutrophils are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). Tuberculosisis one type of infection that may cause neutropenia.
Hemolytic disease of the newborn (HDN) used to be a major cause of fetal loss and death among newborn babies. The first description of HDN is thought to be in 1609 by a French midwife who delivered twins—one baby was swollen and died soon after birth, the other baby developed jaundice and died several days later. For the next 300 years, many similar cases were described in which newborns failed to survive.
Haemolytic anaemia is caused due to erythrocytic loss. Therefore the bone marrow activity is not proper. Depending on the erythrocytic destruction extent and bone marrow activity, the severity of the disease depends. Starting stages of haemolysis is asymptomatic but in final atages of haemolysis causes angina and cardio pulmonary decompensation leading to death.
Abnormality in Plasma cell results in plasma cell disorders. Plasma cell disorders are uncommon, which begin when a single plasma cell multiplies inordinately. The ever-increasing number of abnormal plasma cells also invades and damages various tissues and organs, and the antibody produced by the clone of plasma cells can sometimes damage vital organs, especially the kidneys and bones.
Neutrophilic leukocytosis is an abnormally high number of neutrophils (a type of white blood cell) in the blood. Neutrophils help the body fight infections and heal injuries. Neutrophils may increase in response to a number of conditions or disorders. Blood test called a complete blood count is used to detect neutrophilic leukocytosis.
Journal of Blood Disorders & Transfusion is associated with our "3rd International Conference on Hematology & Blood Disorders" (Hematology-2015) during November 2-4, 2015 Atlanta, USA with a theme “On the Path of Identifying Novel Therapeutics for Blood Disorders”.
*Unofficial 2014 Impact Factor was established by dividing the number of articles published in 2012 and 2013 with the number of times they are cited in 2014 based on Google search and the Scholar Citation Index database. If ‘X’ is the total number of articles published in 2012 and 2013, and ‘Y’ is the number of times these articles were cited in indexed journals during 2014 than, impact factor = X/Y