Churg Strauss syndrome (CSS) was first defined in 1951 as an allergic granulomatosis affecting small and medium-sized vessels
The American College of Rheumatology established six criteria for its classification in 1990: asthma, peripheral eosinophilia, sinus
involvement, pulmonary infiltrates, mononeuritis multiplex, and histology compatible with vasculitis The presence of 4 or more
criteria yielded a sensitivity of 85% and a specificity of 99.7%. Before that, three criteriaâasthma, peripheral eosinophilia, and systemic
vasculitisâwere needed Histological lesions include small-vessel angiitis and extravascular necrotizing granulomas, usually containing
eosinophilic infiltrates Vasculitis may be granulomatous or nongranulomatous and typically involves both arteries and veins in
pulmonary and systemic vessels. The granulomas have a center formed by necrotic eosinophils surrounded by palisading histiocytes
and multinucleated giant cells. They are not present in all patients and are seen in other diseases. There are three partially-overlapping
phases in CSS: 1) a prodromal phase with allergic rhinitis, nasal polyps, and/or sinusitis, followed by asthma; 2) an eosinophilic phase
with peripheral blood eosinophilia and eosinophilic infiltration of organs, and 3) a vasculitic phase. GI and hepatic manifestations of CSS using
the 75 articles in the English literature from 1960 to 2011 found using a Medline search, Google scholar, and the references in the articles
obtained. The emphasis is on recent literature, particularly studies fulfilling the 1990 criteria for diagnosis, although the description of
cases is not always adequate to make this determination.
Last date updated on April, 2024