ISSN: 2155-9880
Journal of Clinical & Experimental Cardiology
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Combined Finding of Left Ventricular Non-Compaction and Dilated Cardiomyopathy

Natale Daniele Brunetti 3*, Antonio Centola1, Erasmo Giulio Campanale1, Andrea Cuculo1, Luigi Ziccardi1, Luisa De Gennaro1 and Matteo Di Biase2
1Post graduate in Cardiology, Cardiology Department, University of Foggia, Italy
2Chief of Department, post graduate in Cardiology, Cardiology Department, University of Foggia, Italy
3Assistant Professor, Cardiology Department, University of Foggia, Italy
Corresponding Author : Natale Daniele Brunetti
Assistant Professor, Cardiology Department
University of Foggia, Italy
Tel: 393389112358
Fax: 390881745424
Received November 18, 2010; Accepted December 27, 2010; Published December 28, 2010
Citation: Brunetti ND, Centola A, Campanale EG, Cuculo A, Ziccardi L, et al. (2010) Combined Finding of Left Ventricular Non-Compaction and Dilated Cardiomyopathy. J Clinic Experiment Cardiol 1:113. doi: 10.4172/2155-9880.1000113
Copyright: © 2010 Brunetti ND, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Visit for more related articles at Journal of Clinical & Experimental Cardiology


We report the case of a 30-year-old man who presented with NYHA I-II class and combined findings of idiopathic dilated cardiomyopathy and left ventricular non compaction at left ventricular angiogram. Coronary angiography was normal and 6-month follow-up uneventful. This case supports the hypothesis linking idiopathic dilated cardiomyopathy and left ventricular non compaction.

Idiopathic Dilated Cardiomyopathy; Left Ventricular Non Compaction
Left ventricular non-compaction (LVNC) or spongy left ventricular (LV) myocardium is a disorder of endomyocardial morphogenesis that results in multiple trabeculations in the LV myocardium [1]. Numerous, excessively prominent LV trabeculae and deep intertrabecular recesses together create a spongiform appearance. According to current literature, LVNC in adults is rare [1], although associated with a poor prognosis [1]. Several studies have reported on highly symptomatic cases with a high incidence of ventricular arrhythmia [1] and progressive heart failure [2].
Recent evidences suggest an overlap between LVNC and idiopathic dilated cardiomyopathy (IDC) [2] and apical hypertrophic cardiomyopathy [2].
Case Report
We report the case of a 30-year-old man, referred for dyspnoea since a couple of years. He was a smoker, obese, without history of heart disease; he was receiving drug therapy with bisoprolol, enalapril, simvastatin and diuretics.
Arterial blood pressure at admission was 100/80 mmHg, and physical examination was unremarkable. Resting ECG showed sinus rhythm (66 bpm) and diffuse negative T waves (Figure 1). Chest radiography showed no sign of pulmonary congestion, with an enlarged cardiac transverse diameter. Cholesterol, troponin and creatinine levels were normal.
Echocardiography showed a severe systolic dysfunction (25% LV ejection fraction). Coronary angiography was not able to show any sign of significant coronary atherosclerosis, with no need of coronary angioplasty. At LV angiography, enlarged diameters and severe hypokinesis were detectable; diffuse irregular trabecles were also detectable in LV angiogram, mimicking features typical of spongy LV myocardium (Figure 2).
New York Heart Association class was I-II at discharge; 6-month follow up was uneventful.
To our knowledge, this is one of the first cases reporting LV angiography images showing the concomitant finding of IDC and LV spongy myocardium in a young man. LVNC is believed to be the result of an arrest in endocardial morphogenesis [2]. Severity ranges from moderately abnormal ventricular trabeculations in association with normal LV function to profoundly abnormal, loosely compacted trabeculations in association with poor LV function [1]. Clinical manifestations of LVNC are symptoms associated with depressed LV systolic function, ventricular arrhythmias, and systemic embolization [2].
In a symptomatic patient, however, differentiation of LVNC from other cardiomyopathies may be difficult. Several cases of IDC have been shown to be LVNC at autopsy [2]. Because the natural histories of the two conditions differ, it is important to differentiate them. However, with a persisting disease state, spongy left ventricle has a tendency to dilate and becomes more spherical [2]. This structural change does not have a specific cause and occurs terminally in any form of chronic myocardial dysfunction.
Misdiagnosis due to technical difficulties may have led to a significant underestimation of LVNC prevalence in the heart failure population [6], this in keeping with recent reviews which noted an increased incidence of LVNC with improving cardiac imaging [2].
Recent evidences suggest an overlap between LVNC and apical hypertrophic cardiomyopathy [7] or IDC [6] as reported in our patient. The presence of IDC without LVNC in relatives of LVNC patients has shown that the phenotype of familial LVNC can overlap with that seen in familial IDC [6].
These data seem to support the hypothesis of a clinical and genetic overlap between LVNC and other cardiomyopathies [6]. However, this issue needs further investigations.
This is a case report with first diagnostic suspicion of LVNC initially based on angiogram imaging; definitive diagnosis needs to be confirmed by echo-Doppler imaging.

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 11402
  • [From(publication date):
    December-2010 - Oct 24, 2016]
  • Breakdown by view type
  • HTML page views : 7657
  • PDF downloads :3745

Post your comment

captcha   Reload  Can't read the image? click here to refresh

OMICS International Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
OMICS International Conferences 2016-17
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2016 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version