Animal Models and Translational Medicine

Animal models for Alzheimer’s disease it is important to think about the human phenotype and what is being modeled in terms of the animal phenotype. The moderator, Bradley Hyman, professor of neurology at Harvard Medical School, said that animal models of Alzheimer’s disease, based on the genetics of the disease and the closely related frontotemporal dementia, replicate at least some of the pathology. Researchers have been successful at modeling very specific aspects of Alzheimer’s disease in the mouse (e.g., plaques, tangles). Although these are incomplete models of the human disease, they have been well received in the field as potentially relevant models for use in drug discovery.

Patients with Alzheimer’s disease will display both amyloidopathy and tauopathy; however, scientists often focus, in a reductionist way, on one or the other in an animal model. A participant added that even though the anatomy in the mouse is different than the human, mutant tau mice are relatively good models in that they recapitulate tau-dependent neurodegeneration. This has led a number of companies to focus on antibodies that block tau-dependent neurodegeneration in these mouse models.

    Related Conference of Animal Models and Translational Medicine

    October 24-26, 2016

    10th European Nephrology Conference

    Rome, Italy
    June 26-28, 2017

    11th Global Nephrologists Annual Meeting

    London, UK
    July 10-12, 2017

    12th Annual Conference on Nephrology & Urology

    Kuala Lumpur, Malaysia
    August 28-30, 2017

    15th International Conference on Nephrology & Therapeutics

    Philadelphia, USA
    August 28-30, 2017

    2nd Annual Kidney Congress

    Philadelphia, USA
    Sep 14-15, 2017

    The Dementia Congress

    Los Angeles, USA
    October 18-19, 2017

    13th World Nephrology Conference


    Animal Models and Translational Medicine Conference Speakers

    Recommended Sessions

    Related Journals

    Are you interested in