Diagnosis & Applications of RNA-Seq

Track 5: Diagnosis & Applications of RNA-Seq

Disease interrogation & clinical applications of RNA-Seq involves different methods that are required for gene expression analysis. Like, we can find out the Alternative Protein-Coding Transcripts in Prostate Cancer to interrogate its nature and occurrence. Targeted RNA sequencing is a highly accurate and specific method for measuring expression of transcripts of interest, offering both quantitative and qualitative information. This allows for differential expression analysis, as well as allele-specific expression measurement and verification of the presence of fusion genes. The ability to obtain a complete picture of Intergenic Disease-Associated Regions provides clear understanding of how the underlying genome is converted into the functional proteins, allowing for clinical utility in patient classification, diagnosis, and individualized treatment. To understand which coding and non-coding RNAs are transcribed in the diseased cell, deciphering the Diseased Transcriptome by RNA-Seq and qPCR can be done. The Northwestern University Feinberg School of Medicine has a special unit called Centre for Genetic Medicine where bioinformatics analysis of a RNA-seq is performed. Other universities include The Rockefeller University and University of Bristol, UK

Relevant Conferences:

International Conference on Nucliec Acids, August 4-6, 2016 Seattle, USA; International Conference on Next Generation Sequencing, July 21-22, 2016, Berlin, Germany; 2nd International Conference on Transcriptomics September 12-14, 2016 Philadelphia, USA; 6th International Conference & Expo on Proteomics March 29-30, 2016 Atlanta, USA; 2nd International Conference on Prostate Cancer and Treatment May 05-07, 2016 Chicago, USA; Non-coding RNAs and RNAP II Regulation in Development and Disease, March 29, 2016, Texas, USA; RNA UK 2016, January 29-31, 2016, Lake District, UK; NGS 2015 November 18-19, Sheffield, UK; NGS 2016 Genome Annotation, April 4-6, 2016, Barcelona, Spain.

Various technologies have been developed to deduce and quantify the transcriptome including hybridization and sequencing-based approaches, qPCR. Recently, high density exon microarrays have been successfully employed for detecting differentially expressed genes and alternative splicing events for biomarker discovery and disease diagnostics. Targeted RNA sequencing is a highly accurate method for selecting and sequencing specific transcripts of interest and offers both quantitative and qualitative information. RNA-Seq for Plant associated disease is generally used to find out the defect at transcriptional level. Intergenic disease associated regions helps in  understanding of three-dimensional spatial relationships in the genome, and the substantial repository of information about relationships among genetic variants, genes, and diseases captured in the published biomedical literature.RNA sequencing is used to characterize different cancer specific transcripts. An important genetic mechanism underlying biological diversity is alternative pre-mRNA splicing, which is thought to affect approximately 95% of transcripts derived from protein-encoding genes in Prostrate Cancer.

  • Deciphering the Diseased Transcriptome by RNA-Seq and qPCR
  • Targeted RNA Sequencing
  • RNA-Seq for Plant associated disease
  • Intergenic Disease-Associated Regions
  • RNA-Seq to Identify and Characterize Different Cancer Specific Transcripts
  • Alternative Protein Coding Transcripts in Prostate Cancer
  • Functional Dysregulation in Inflammatory Diseases

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