Drug discovery

Driven by chemistry but increasingly guided by pharmacology and the clinical sciences, drug research has contributed more to the progress of medicine during the past century than any other scientific factor. Improving the science of drug development and regulation is important in fulfilling the public health. The advent of molecular biology and, in particular, of genomic sciences is having a deep impact on drug discovery. Emphasis is placed on the contrast between the academic and industrial research operating environments, which can influence the effectiveness of research collaboration between the two constituencies, but which plays such an important role in drug innovation. The strategic challenges that research directors face are also emphasized

The worldwide market for therapies for central nervous system (CNS) disorders was valued at around US dollars 15 billion in 2011, and is set to grow sharply in the years ahead. This is because of a marked increase in the number of people aged over 65 (the "baby boomer" effect), which will lead to increased demand for more safe and effective medicines for CNS disorders. 1) how to identify and validate targets for potential CNS drugs; 2) how to assess brain penetration (both in vitro and in vivo); 3) how to develop in silico methodologies to predict blood-brain barrier penetration; 4) how to assess therapeutic efficacy (both in vitro and in vivo); 5) how to establish reliable biomarkers to guide decision making; and 6) how to effectively apply magnetic resonance imaging to CNS drug discovery.

  • Cardio Vascular Drug Discovery
  • Ligand Based Drug Discovery
  • Scaffold Based Drug Discovery
  • Perspective in Drug Discovery
  • Antibiotics Drug Discovery
  • Entrepreneurs Investment Meet
  • Structure Based Drug Design

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