Exploring Transcriptome

Track 3: Exploring Transcriptome

While exploring the complexity of the Transcriptome, the basic protocol of the identification of long stress-induced non-coding transcripts is followed. Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but are not translated into proteins. Functional Impact of Non-Coding RNA (ncRNA) involves regulation of gene expression at the transcriptional and post-transcriptional level. Those ncRNAs that appear to be involved in epigenetic processes can be divided into two main groups; the short ncRNAs (<30 nts) and the long ncRNAs (>200 nts). Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a potentially new and crucial layer of biological regulation. Long noncoding RNA (lncRNAs) biochemically resemble mRNAs posited by Jacob and Monod, yet do not template protein synthesis. Rather, lncRNAs functioning as RNA genes to orchestrate genetic regulatory outputs. Today, lncRNA transcripts have emerged as a cryptic, but critical layer in the genetic regulatory code. It has been implicated in a range of developmental processes and diseases in which Long ncRNAs target proteins to specific genomic loci to affect transcription patterns. It also modulates the activity of protein-binding partners. They also act as precursors for small RNAs. Analysis of the transcriptome on neurological basis can be done under the title of profiling microRNAs and circular RNAs in brain. Here we can find out how the genomic basis is responsible for the behavioural changes through neurological basis. Even this phenomenon can be controlled through Regulation of Transcriptional Heterogeneity. The basic strategy behind the all this mechanism comes from the molecular level which contain Chromatin and Histone Protein.

John L. Rinn is the Alvin and Esta Star Associate professor of Stem Cell and Regerative Biology at Harvard University and Medical School and Senior Associate Member of the Broad Institute. Our research aims to understand the role of long non-coding RNAs (lncRNAs) in establishing the distinct epigenetic states of adult and embryonic cells and their misregulation in diseases such as cancer.

Relevant Conferences:

International Conference on Nucliec Acids, August 4-6, 2016 Seattle, USA; World Congress on Amino Acids and Proteins, December 8-9, 2016, Baltimore, USA; International Conference on Next Generation Sequencing, July 21-22, 2016, Berlin, Germany; 2nd International Conference on Transcriptomics September 12-14, 2016 Philadelphia, USA; 6th International Conference & Expo on Proteomics, March 31-Apr 2, 2016, Atlanta, USA; Noncoding RNAs and Cancer, December 4 - 7, 2015, Boston, USA; Chromatin, Noncoding RNAs in Health and Disease, February 21-24, 2016, New Mexico, USA; Non-coding RNAs and RNAP II Regulation in Development and Disease, March 29, 2016, Texas, USA; RNA UK 2016, January 29-31, 2016, Lake District, UK; Small RNA Silencing: Little Guides, Big Biology, January 24-28, 2016.

Non coding RNA do not code for any protein but they regulate gene expression at Translational and Transcriptional level. Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts that includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity.  miRNA profiling is gaining popularity because miRNAs, as key regulators in gene expression networks, can influence many biological processes and also show promise as biomarkers for disease. Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Transcript heterogeneity is generated by a relatively simple eukaryotic genome with limited splicing, and within a genetically homogeneous population of cells. The fundamental unit of chromatin , termed the nucleosome is composed of DNA and Histone proteins.

  • Non-Coding RNA
  • Long Non-Coding Transcripts
  • Functional impact of non-coding RNA (ncRNA)
  • microRNAs Profiling
  • Circular RNAs
  • Regulation of Transcriptional Heterogeneity
  • Chromatin and Histone protein

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