Molecular Epigenetics

Epigenetics is the study of heritable changes in the phenotype of a cell or organism that are not caused by its genotype. The molecular basis of an epigenetic profile arises from covalent modifications of protein and DNA components of chromatin. The epigenetic profile of a cell often dictates cell fate, as well as mammalian development, aging and disease. Epigenetics has evolved to become the science that explains how the differences in the patterns of gene expression in diverse cells or tissues are executed and inherited.

Related Conferences: International Conference on Synthetic Biology, September 28-30, 2015 (Houston, USA); 6th World Congress on Biotechnology, October 05-07, 2015 (New Delhi, India); 3rd International Conference on Genomics & Pharmacogenomics, September 21-23, 2015 (San Antonio, USA); World Bio Summit & Expo, November 02-04, 2015 (Dubai, UAE); International Conference on Genetic Counselling And Genomic Medicine, August 11-12, 2016 (Birmingham, UK); Cell Symposia: Stem Cell Epigenetics 20-22 September 2015 (Barcelona, Spain); EMBO Conference The DNA damage response in cell physiology and disease 5-9 October 2015 (Cape Sounio, Greece); EMBO Conference Nuclear structure and dynamics 7-11 October 2015 (L'Isle-sur-la-Sorgue, France); CSH Asia Mitochondria 12-16 October 2015 (Cold Spring Harbour, New York); ABCAM Chromatin Structure and Function 16-19 November 2015 (Grand Cayman Island).

Epigenetic modifications are a hallmark of gene regulation and thus govern a wide range of biological processes. We are interested in revealing the molecular interplay of chromatin modifying proteins, chromatin-reading proteins and epigenetic marks to understand the mechanisms underlying differentiation, ageing and DNA repair. Epigenetics is rising to prominence in biology as a mechanism by which environmental factors have intermediate-term effects on gene expression without changing the underlying genetic sequence. This can occur through the selective methylation of DNA bases and modification of histones. Although there is no uniform definition of epigenetics, it has been described as heritable changes in gene function that occur without a change in the nucleotide sequence. Epigenetic modifications can be passed from one cell generation to the next and between generations of a species.

  • Cell based immunotherapy
  • Cancer immune cells
  • Cell based immuno suppression in transplantation
  • New cell therapies for allergies
  • Tumor cells evade or defeat immune system

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