Molecular Neuropharmacology

Molecular neuropharmacology involves the study of neurons and agonist, Competitive antagonist and Non-competitive antagonist, receptors on neurons for developing new drugs that will treat neurological disorders of neurodegenerative diseases. Neurogenesis and repair refers to the growth and development of neuron. Neurons never function in isolation; they are organized into ensembles or circuits that process kinds of information which are referred as neuronal circuits. The GABA inhibitory neurotransmitter and serotonin neurotransmitter present in the central nervous system of mature vertebrate interacts with GABA receptor and 5HT receptor respectively. 

The global CNS biomarker market was estimated at $1.7 billion in 2011 and nearly $2 billion in 2012. The market is projected to reach $5.1 billion by the end of the forecast period of 2012 to 2017, representing a compound annual growth rate (CAGR) of 20.7%.

GABAA receptors are modulated by the channel of 5HT receptors through activation of various proteins. There are about 14 5HT receptor subtypes identified from last 20 years which are now researched for their significance in various disorders and treatments. Synaptopathy is a progressively popular term used to define main features of neurodegenerative and psychiatric disease. It infers that brain diseases are resulted from disruption of synaptic structure and function.

  • Neurogenesis and repair
  • Studies on neuronal circuits
  • GABA , 5HT receptors and its neuronal development
  • Synaptopathy in neurodegenerative diseases and ageing
  • Manipulation of ion channels by drugs

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