Systems Toxicology

Systems Toxicology is the integration of classical toxicology with quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Society demands increasingly close scrutiny of the potential health risks associated with exposure to chemicals present in our everyday life, leading to an increasing need for more predictive and accurate risk-assessment approaches. Developing such approaches requires a detailed mechanistic understanding of the ways in which xenobiotic substances perturb biological systems and lead to adverse outcomes. Thus, Systems Toxicology approaches offer modern strategies for gaining such Investigatory findings by Infusion toxicology techniques and Computational toxicology.

Furthermore, Systems Toxicology is a means for the identification and application of biomarkers for improved safety assessments by Pharmacology investigations in toxicology testing. In Systems Toxicology, quantitative systems-wide molecular changes in the context of an exposure are measured, and a causal chain of molecular events linking exposures with adverse outcomes (i.e., functional and apical end points) is deciphered. Mathematical models are then built to describe these processes in a quantitative manner. The integrated data analysis leads to the identification of how biological networks are perturbed by the exposure and enables the Developmental and reproductive toxicology processes. This perspective integrates current knowledge regarding bioanalytical approaches, computational analysis, and the potential for improved risk assessment.

Many Companies have focused their products on Systems Toxicology Research like Mitsui Zosen Systems Research Inc., Alere US and Eurotox to name a few. The IBIS World provides a detailed Market Report of the growing Toxicology Market and thus the effectiveness of the research.

Systems Toxicology is a means for the identification and application of biomarkers for improved safety assessments by Pharmacology investigations in toxicology testing. Toxicology approaches offer modern strategies for gaining such mechanistic knowledge by combining advanced analytical and computational tools. Toxicologists aim to understand and predict the adverse effects of chemicals on biological systems. As biological systems are extremely complex, the challenge of predicting human toxicity early in the drug discovery process is immense. In the past decades, a huge effort has been undertaken to characterise the impact of chemicals on biological systems using in vitro, pre-clinical and clinical approaches. This has led to a vast amount of knowledge on the biology of systems, especially as a result of the data deluge from -omic level investigations.

  • Computational toxicology
  • Pharmacology investigations in toxicology testing
  • Infusion toxicology techniques
  • Investigatory findings
  • Developmental and reproductive toxicology

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