Saint Louis University USA
We propose that the novel use of Zn as a chemotherapeutic agent for cancer will significantly improve patient outcome. We are using prostate cancer and ovarian cancer tissue culture cells to test the generally applicability of Zn as a cancer treatment. Our research involves evaluating varied means by which we can selectively deliver cytotoxic levels of Zn to cancer cells while sparing non-targeted cells. Additionally, we are investigating the mechanism by which Zn kills cancer cells with the idea of indentifying new pathways and/or targets for additional drug development.