University of Maryland
Dr. Garzino Demo received his PhD at the University of Torino Italy in 1988 Between 1989 and 1991he conducted research examining the effect of cofactors such as HHV6 on theprogression of HIV infection From1991 until 1996 Dr GarzinoDemo worked with DrRobert C Gallo at the Laboratory of Tumor Cell Biology at NCI NIH continuing hisstudies on cofactors in HIV infection and on HIV gene expression Dr GarzinoDemo joined the Institute of Human Virology in January 1996 to further his studies on HIVsuppressive factors produced by the immune system He was a member of the team thatoriginally identified RANTES MIP1945; and MIP1ß as suppressive HIVsuppressivefactors in 1995 Successively he participated to the characterization of anotherchemokine MDC with broad HIVsuppressive activity In addition he has been the keyinvestigator in a large study of antigeninduced chemokine release in a wellcharacterizedadult cohort MACS cohort He is also the author of several otherscientific publications and reviews on chemokines their role in HIV infection and theirregulation The main focus of his research is on the role of host factors in controlling HIVinfection Recently he and his laboratory have described the HIVinhibitory activity ofbetadefensins demonstrating that hBD2 inhibits HIV through a novel antiviralmechanism mediated by a chemokine receptor CCR6 that induces increased expression of the antiviral protein APOBEC3G These findings are of importance in mucosal immunity and HIV infection.
University of MarylandHIV; AIDS pathogenesis;host factor that limit HIV infection; Innate immunity; mucosal immunity; chemokines; defensins; intracellular signaling; viral oncology.
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