ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

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Hui Wu
Hui Wu

Hui Wu
Associate Professor
Department of Pediatric Dentistry
University of Alabama at Birmingham
USA
Tel. 205-996-2392
Fax 205-975-4431

Biography

July 1991 - July 1994-Research Associate. Institute of Plant Physiology, Chinese Academy of Science, Shanghai. P. R. China
January 1995 - May 1999-Graduate Research Assistant. Department of Microbiology & Molecular Genetics, University of Vermont, Burlington, VT
August - December 1994-Research Assistant. Department of Biology, University of Vermont, Burlington, VT
August 1999 – May 2004-Research Associate: Department of Medicine, University of Vermont, Burlington, VTbr /> July 2002 – May 2004-Research Associate. Department of Microbiology & Molecular Genetics, University of Vermont, Burlington, VT
June 2004- September 2008-Assistant Professor, Department of Pediatric Dentistry, University of Alabama at Birmingham (UAB), School of Dentistry, Birmingham, AL
June 2005-present-Assistant Professor of Microbiology and Pathology. Departments of Microbiology and Pathology, UAB School of Medicine and Dentistry, Birmingham, AL
October 2008-present Associate Professor, Department of Pediatric Dentistry, UAB School of Dentistry, Birmingham, AL

Research Interest

Bacterial biofilm development is crucial for numerous persistent and chronic bacterial infections in humans. We study molecular mechanisms governing bacterial biofilm formation using oral bacteria as model systems. They are particularly interested in glycosylation and biogenesis of serine-rich repeat adhesins that are widespread in oral streptococci and many pathogenic Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus. Their study is aimed to uncover new and conserved bacterial glycosylation and secretion pathways that are amenable to therapeutic strategy to control bacterial colonization and pathogenesis. We also study the interactions between bacterial biofilms and hosts, and how the biofilm formation modulates vegetation in infective endocarditis and bone remodeling dynamics in periodontal disease. In collaboration with chemists, we are developing small molecule inhibitors that block biofilm formation of oral pathogens and osteoclastogenesis, which may have therapeutic potentials for treatment of oral infectious diseases and other resorption related bone disorders.

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Publications

Esterification of the Free Carboxylic Group in 3,4-di-O-caffeoylquinic Acid Enhances the Inhibition Activity against Respiratory Syncytial Virus (RSV)

Donghui Wu, Wei Tang, Chao Xia, Laitao Zhang, Ling Zhuang, Pinghua Sun, Nenghua Chen, Cheng Luo, Guocai Wang, Yaolan Li and Heru Chen

Research Article: Med Chem (Los Angeles) 2015, 5: 534
doi: 10.4172/2161-0444.1000313
 
Pallidifloside D from Smilax riparia Enhanced Allopurinol Effects in Hyperuricemia Mice

Xiao-Hui Wu, Yi He, Chao Mi, Jun Zhang, Shu-Qing Wang, Fei Yu, Samantha Anderson and Yan-
Wen Zhang

Research Article: JOMC
 
Polyphenols from the Rhizomes of Potentilla freyniana

Xiao-Hui Wu, Chao Mi, Yi He, Shu-Qing Wang, Jun Zhang and Yan-Wen Zhang

Research Article: Med Chem (Los Angeles) 2015, 5: 021
doi: 10.4172/2161-0444.1000237
 
Analysis of the Influence of Endograft Geometry on Blood Hemodynamics in Abdominal Aortic Aneurysm by Computational Fluid Dynamics

Chang-Hsiang Huang, Yio-Wha Shau, I-Hui Wu

Research Article: J Clin Exp Cardiolog 2014, 5:340
doi: 10.4172/2155-9880.1000340
 
Use of Root Cause Analysis to Prevent Falls and Promote Patient Safety in Clinical Rehabilitation

Shih-Hui Wu and Ru-Lan Hsieh

Research Article: J Nov Physiother 2013, 3:132
doi: 10.4172/2165-7025.1000132
 
Characterization of the Interaction between Cationic Thulium (III)? Porphyrin Complex with Bovine Serum Albumin

Xi-Liang Lu, Huai-Cheng Yang, Hui Wu and An-Xin Hou

Research Article: J Mol Biomark Diagn 2012, 3: 126
doi: 10.4172/2155-9929.1000126
 

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