ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year
across USA, Europe & Asia with support from 1000 more scientific Societies and
Publishes 700+ Open Access Journals which contains over 50000
eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers
Each Journal is getting 25,000+ Readers
This Readership is 10 times more when compared to other
Subscription Journals (Source: Google Analytics)
Ian Stuart Zagon
Ian Stuart Zagon

Ian Stuart Zagon
Professor
Pennsylvania State University
USA
Tel: 717-531-8650
Fax: 717-531-5003

Biography

Ian Stuart Zagon is a professor of Neuroscience and Anatomy at Pennsylvania state university. He is expertise in the field of treatment of cancer and autoimmune diseases showing its  safety and efficacy. He has published a number of articles related to his research field in various reputed journals.

Research Interest

One direction of our research has been to understand the role of opioids in diabetes. It is well known that diabetics have an elevate level of enkephalins and problems with pain perception. We have connected the increased levels of opioids with delays in wound healing commonly occurring in diabetics. In grants sponsored by NIDDK, we have found that a topical application of NTX accelerates corneal wound healing in animals with Type 1 diabetes by disrupting the enhanced interactions of the OGF-OGFr axis in these animals. Introduction of sense or antisense of OGFr into the cornea by a gene gun revealed that the OGF-OGFr pathway is vital to regulating cell proliferation and wound healing. In the course of these experiments, we have devised a topical application of a cream of NTX that accelerates the closure of skin wounds in diabetics. NTX is known as a pure biological compound with little to no direct effects, and we hypothesize that NTX is accelerating wound healing of skin by blocking a critical opioid peptide-opioid receptor pathway. This grant application seeks to understand the underlying basis for these phenomena and tests our hypothesis in mice with Type 1 diabetes by employing knockout animals for classical and non-classical (OGFr) receptors and studying the absence of receptors on wound healing. In a third specific aim, we will use tissue culture of epithelial cells along with a wound model to integrate information in Specific Aims 1 and 2 with the cell and molecular biology of opioid action. In summary, we have pioneered in the use of NTX to upregulate wound healing, developed a topical NTX that is safe and efficacious for skin wound repair, have the reagents, tools, and experience to conduct the [-enkephalin - termed opioid growth factor (OGF) in view of its non-neural and neural distribution as well as its function in growth), and opioid receptor (OGFr) associated with cell proliferation. We have partnered with clinicians to translate our science from bench to bedside, and clinical trials have been published regarding the use of OGF - and low dose naltrexone (LDN) - for the treatment of cancer and autoimmune diseases showing safety and efficacy, and topical application of NTX is now being examined in a clinical trial sponsored by the Department of Defense by my co-investigator, Dr. Joseph Sassani. proposed research, demonstrated a record of successful and productive research projects in an area of high relevance to human health and disease, and we are addressing an important unmet medical needs.

Certificate
Certificate

Global Speakers in the subject

Global Experts in the subject

türk porno izletürk pornoları doyasıya izleyin ve boşalın.

 
OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
 
 
OMICS International Conferences 2016-17
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings
 
 

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsinc.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsinc.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsinc.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsinc.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsinc.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsinc.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsinc.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsinc.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsinc.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsinc.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsinc.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsinc.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsinc.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsinc.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsinc.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsinc.com

1-702-714-7001 Extn: 9042

 
© 2008-2016 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version