Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Zhengping Yi
Associate Professor of Pharmaceutical Sciences, Director, Proteomics Research Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy/Health Sciences
Wayne State University, USA
Dr. Zhengping Yi is an Assistant Research Professor in the Center for Metabolic & Vascular Biology and the School of Life Sciences at ASU and directs the Proteomics Laboratory. Dr. Yi completed his Ph.D in Chemistry at Nanjing University, P. R. China in 2000 and did post-doctoral work in Biochemistry at Purdue University and post-doctoral work in proteomics and diabetes at the University of Texas Health Science Center at San Antonio. His current research funded by NIH and ADA focuses on insulin signaling and its associated problems with insulin resistance and type 2 diabetes.
Dr. Yi’s research focuses on a better understanding of the basic biology of insulin signaling and the etiology of insulin resistance, type 2 diabetes (T2D), as well as their complications. Dr. Yi and his group are using a combination of clinical, biological, and proteomic approaches to better comprehend insulin signaling and the associated problems that occur with obesity and T2D. Studying insulin signaling in humans is challenging. Dr. Yi’s laboratory has developed state-of-the-art techniques that can be used to better define and understand the effect of insulin in key metabolic tissues in humans such as skeletal muscle. These approaches are useful models for studying cell signaling pathways in general, and especially their regulation by protein phosphorylation and protein-protein interactions. In addition to directing his independent laboratory working on insulin signaling both in vitro and in vivo, Dr. Yi also directs the Proteomics Laboratory in the Center for Metabolic and Vascular Research. The Proteomics Laboratory is well equipped with two 2D-HPLC-ESI-MS/MS systems, including one Thermo LTQ-FT-Ultra. It is one of the most sensitive instruments with high mass resolution and mass accuracy available for complex proteomic studies. Proteomics offers the capability to simultaneously quantify multiple proteins, protein-protein interactions, and protein phosphorylation, providing a better picture of complex protein networks.