Iron Chelation Therapy

Iron is absolutely essential to living cells and plays many important roles in energy production, oxygen transport and DNA synthesis. Although iron is crucial for cells, an excess of iron is toxic. In thalassemia patients, multiple blood transfusions and abnormal iron absorption cause iron overload and accumulation in tissues and organs. Consequently, reactive oxygen species (ROS) are produced from the iron-catalyzed Fenton reaction, causing oxidative tissue damage and organ dysfunctions. Iron chelation therapy is required, not just to restore iron balance, but also to reduce toxic iron species. Iron chelators, such as desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX), are available for clinical use. Due to many side effects and drawbacks of available chelators, novel oral bidentate iron chelator CM1 is synthesized, it is an analogue and is more lipophilic than DFP. CM1 was able to bind both ferric and ferrous ions, and was also able to chelate plasma non-transferrin bound iron (NTBI), efficiently. CM1 was not toxic to peripheral blood mononuclear cells and liver cells in an in vitro study. Somdet Srichairatanakool https://www.omicsonline.org/open-access/toxicity-study-of-a-novel-oral-iron-chelator-nacetylaminohexyl-hydroxymethylpyridinone-cm-in-transgenic-bthalassemia-mice-vms.1000116.php?aid=16304 Open access OMICS International Publishing Group aimed to provide the readers a barrier free flow of research work and conceptualized knowledge through online. To speed up the pace of scientific innovations, discovery, quality enriched education system and increase the global economy, open access is a key to success in dissemination of knowledge to world community. Vitamins & Minerals is one such open access journal from OMICS Group, publishing the research, review, case reports, short commentaries and editorials pertaining to the field of nutrition sciences on quarterly basis for its readers. Today in the field of competition, quality of articles publishing in the journal per issue is very important with a rapid peer review process. Vitamins and Minerals journal trying to bring such quality in the articles published per issue with its broader conceptualized editorial board and with the expertise reviewers.

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Last date updated on April, 2024