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Acute Kidney Failure Share this page Facebook  Twitter  LinkedIn  Google+  Pinterest   Blogger

  • Acute kidney failure

     Acute kidney failure occurs when your kidneys suddenly become unable to filter waste products from your blood. When your kidneys lose their filtering ability, dangerous levels of wastes may accumulate, and your blood's chemical makeup may get out of balance due to loss of electrolytes.

    Typical symptoms

    Decreased urine output, normal Fluid retention, causing swelling in your legs, ankles or feet, Drowsiness, Shortness of breath, Fatigue, Confusion, Seizures or coma in severe cases, Chest pain or pressure.

  • Acute kidney failure


    Urine output measurements, Urine tests, Blood tests, Imaging tests, Removing a sample of kidney tissue for testing


  • Acute kidney failure


    Each year, approximately 700,000 deaths in Europe, the US and Japan are associated with AKI. Annually, hospital-acquired AKI affects approximately 2 million patients in the Western World (Europe, the US and Japan) and the incidence is rising. The disease occurs in as many as 4% of hospital admissions and up to 40% of admissions to intensive care units. Despite the significant unmet medical need in AKI, especially sepsis-associated AKI, no pharmacological treatment is available and only a limited number of candidate medicines is in clinical development. The multi-factorial pathogenesis of the disease probably necessitates a multi-factorial intervention to allow protection, thereby limiting the number of potentially effective treatment options.

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