Identification Of Combinatorial Drivers And Targets In Cancer
Coupling of scalable in silico and biologic high throughput cancer cell line platforms for the recognition of co-events in cancer delivers rational combinatorial targets for synthetic lethal approaches with a high potential to pre-empt the emergence of resistance.
Diagnostic Testing for Targeted Cancer Therapies
Biological pathways and biomarkers, including EGFR, KRAS, BRAF, ALK, ROS1, HER2, and KIT for targeted treatment of lung, gastrointestinal, colorectal, and breast cancers as wells malignant melanoma. Companion diagnostic testing on biological markers for targeted cancer therapies has become a vital component of personalized cancer treatment.
Cartilage Tissue Engineering
Technical challenge in cartilage tissue engineering is the development of a non-invasive method for monitoring the composition, structure and function of the tissue at different growth stages.
Cerium Chloride-Induced Injury Of Mouse Hippocampus
Cerium is widely used in many aspects of modern society, including agriculture, industry and medicine. It has been demonstrated to enter the ecological environment, is then transferred to humans through food chains, and causes toxic actions in several organs including the brain of animals.
Healthy and Diseased Brain Aging and Cognition
Age-related changes in the brain\\\'s chromatin structures, highlight potential epigenetic drug targets for cognitive decline and age-related neurodegenerative disease, and discuss opportunities and challenges when studying epigenetic biomarkers in aging research.