NLM ID: 101580370
Journal of Molecular Biomarkers & Diagnosis is best Open Access, online, medical journal. Biomarker is an indicator of a particular disease or physiological state of an organism. Journal of Molecular Biomarkers and diagnosis is a peer reviewed medical journal that includes a wide range of topics in this field and creates a platform for the authors to make their contribution towards the journal.
The Journal seeks high-quality submissions and welcome contributions in Biomarker, genetic marker, screening, dna-profiling, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, biomarker toxicology. Journal of Molecular Biomarkers & Diagnosis is an Open Access scholarly journal and aims to publish most complete and reliable source of information.
This scholarly publishing is using Editorial Manager System for quality in the review process. Editorial Manager is an online manuscript submission, review and that tracks the review status. Review process is performed by the editorial board members of Journal of Molecular Biomarkers & Diagnosis or outside experts; at least two independent reviewer’s approval followed by the editor is required for the acceptance of any citable manuscript.
A biomarker is a characteristic that can be objectively measured as an indicator of normal biological processes, pathogenic processes or a pharmacological response to a therapeutic intervention. These are used for many purposes including disease diagnosis and prognosis, prediction and assessment of treatment response.
Biomarkers can be characteristic biological properties or molecules that can be detected and measured in parts of the body like the blood or tissue. They may indicate either normal or diseased processes in the body.
Biomarkers can be specific cells, molecules, or genes,gene products, enzymes, or hormones.
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Tumour markers are made by normal cells as well as by cancer cells. These are the substances that are produced by cancer or by other cells of the body in response to cancer or certain begin conditions. These substances can be found in the blood, urine, stool, tumour tissue, or other tissues or bodily fluids of some patients with cancer.
Most tumor markers are proteins. However, more recently, patterns of gene expression and changes to DNA have also begun to be used as tumor markers. Markers of the latter type are assessed in tumor tissue specifically.Thus far, more than 20 different tumor markers have been characterized and are in clinical use.
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A biomarker is a substance used as an indicator of biological state. Oncology biomarkers actually make their way into routine clinical use. These can be detected and measured in parts of the body like blood or tissue. Biomarkers can be specific cells, molecules, or genes, gene products, enzymes, or hormones.
In the recent years, knowledge about cancer biomarkers has increased tremendously providing great opportunities for improving the management of cancer patients by enhancing the efficiency of detection and efficacy of treatment. Recent technological advancement has enabled the examination of many potential biomarkers and renewed interest in developing new biomarkers.
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It is an experimental technique is used to identify genes responsible for a particular phenotype of an organism. Genetic screens can provide important information on gene function as well as molecular events. The different types of genetic testing are diagnostic testing, predictive genetic testing, carrier testing, new born screening, and prenatal diagnosis.
Genetic testing is "the analysis of chromosomes (DNA), proteins, and certain metabolites in order to detect heritable disease-related genotypes, mutations, phenotypes, or karyotypes for clinical purposes." It can provide information about a person's genes and chromosomes throughout life.
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Genetic diagnosis is used to identify or confirm the diagnosis of a disease. It is helpful in a determining the course of a disease. It can be performed before birth or at any time during a person’s life.it can influence a person’s choices about health care and management of the disorder.
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Tuberculosis is diagnosed by finding Mycobacterium tuberculosis bacteria in a clinical specimen taken from the patient. Symptoms include low grade remittent fever, chills, night sweats, appetite loss, weight loss, and easy fatigability. There are several tests available to diagnosis of tb. They are blood test, imaging test, sputum test and the tb skin test.
Tragically, development and implementation of TB diagnostics kept pace neither with medical technology nor with the catastrophic explosion of TB, including drug-resistant TB, in the wake of the global human immunodeficiency virus (HIV) pandemic. Inadequate tools and weak systems for laboratory-based diagnosis of active TB have contributed to underdiagnosis of disease, leading to individual morbidity and mortality and to continued transmission
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Insights in Medical Physics, Journal of Imaging and Interventional Radiology, JBR Journal of Clinical Diagnosis and Research, Insights in Medical Physics, OMICS Journal of Radiology, Institute of Tuberculosis and Pulmonary Diseases, National Research Institute of Tuberculosis and Lung Disease, Fetal Diagnosis and Therapy, Journal of Dual Diagnosis, Mental Health and Substance Use: Dual Diagnosis, Prenatal Diagnosis.
A diagnosis arrived at by an examination of the substance and function of the tissues of the body. The term pathology itself may be used broadly to refer to the study of disease in general, incorporating a wide range of bioscience research fields and medical practices.
Research requires innovation and collaboration across specialties, including pathology, to develop new medical discoveries that will improve health. Digital pathology provides the innovation necessary to create high quality whole slide images of glass slides. The whole slide images are then used to identify, quantify, and document key characteristics, reactions, or responses within a specific set of tissue samples. The total time spent on research studies can be significantly decreased with digital pathology resulting in an improved turnaround time on novel discoveries and advancements in medicine
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Diagnosis of virus infection is usually on the basis of symptomology with no lab confirmation because: Virus infections are rarely life-threatening, limited alternatives for intervention exists. It is important in case of life testing infection, Infections for which interventions or management strategies exist, chronic infections.
In general, diagnostic tests can be grouped into 3 categories.: (1) direct detection, (2) indirect examination (virus isolation), and (3) serology.
In direct examination, the clinical specimen is examined directly for the presence of virus particles, virus antigen or viral nucleic acids. In indirect examination, the specimen into cell culture, eggs or animals in an attempt to grow the virus: this is called virus isolation. Serology actually constitute by far the bulk of the work of any virology laboratory. A serological diagnosis can be made by the detection of rising titres of antibody between acute and convalescent stages of infection, or the detection of IgM. In general, the majority of common viral infections can be diagnosed by serology. The specimen used for direction detection and virus isolation is very important. A positive result from the site of disease would be of much greater diagnostic significance than those from other sites.
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Biomarkers in the saliva have the potential to be used for screening purposes in epidemiological studies. The aim of this study was to investigate if certain salivary biomarkers could be used for detection of common systemic diseases.
For clinical applications such as monitoring health status, disease onset and progression, and treatment outcome, there are three necessary prerequisites:
(i) a simple method for collecting biologic samples, ideally noninvasively
(ii) specific biomarkers associated with health or disease
(iii) a technology platform to rapidly utilize the biomarkers. Saliva, often regarded as the 'mirror of the body', is a perfect surrogate medium to be applied for clinical diagnostics. Saliva is readily accessible via a totally noninvasive method.
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Serum biomarker is used to detect the irritable bowel syndrome (IBS). No single serum biomarker can reliably differentiate irritable bowel syndrome (IBS) from other functional gastrointestinal disorders or organic diseases of the gastrointestinal tract.
Sepsis, an innate immunological response of systemic inflammation to infection, is a growing problem worldwide with a relatively high mortality rate. Immediate treatment is required, necessitating quick, early and accurate diagnosis. Rapid molecular-based tests have been developed but still suffer some disadvantages. The most commonly studied biomarkers of sepsis are reviewed for their current uses and diagnostic accuracies, including C-reactive protein, procalcitonin, serum amyloid A, mannan and IFN-γ-inducible protein 10, as well as other potentially useful biomarkers.
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Insights in Medical Physics, Journal of Molecular and Genetic Medicine, Clinical & Experimental Pathology, Clinical Case Reports, Journal of Medical Diagnostic Methods, Biomarkers: biochemic, Biomarkers in medicine,The Biomarkers Consortium, Biomarkers, Journal of Biomarkers.
The potential of oxygen free radicals and other reactive oxygen species (ROS) to damage tissues and cellular components, called oxidative stress. The techniques are as diverse as blood tests for oxidized lipids, volatile hydrocarbons in breath and oxidized DNA bases in urine.
Increased oxidative/nitrosative stress generally describes a condition in which cellular antioxidant defenses are inadequate to completely inactivate the reactive oxygen species (ROS) 1 and reactive nitrogen species (RNS) generated because of excessive production of ROS/RNS, loss of antioxidant defenses, or both. A major consequence of oxidative/nitrosative stress is damage to nucleic acid bases, lipids, and proteins, which can severely compromise cell health and viability or induce a variety of cellular responses through generation of secondary reactive species, ultimately leading to cell death by necrosis or apoptosis.
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Diagnostic and therapeutic services to focus on our patients’ total health and wellness. The aim of the procedure is purely to visualise a part of the gastrointestinal, respiratory or urinary tract in order to aid diagnosis.
This section discusses a variety of diagnostic and therapeutic procedures, such as angiography, CAT scan, MRI scan, nuclear medicine, radiotherapy, x-ray imaging, ultrasound, Pap smear, and more. Diagnostic imaging refers to a variety of non-invasive methods for identifying and monitoring diseases or injuries by analyzing images. These images represent the internal anatomic structures and organs of a patient's body. Based on the outcome of imaging tests and other diagnostic procedures, patients may be referred for additional testing or treatment.
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An in vitro diagnostic is a method of performing a diagnostic test outside of a living body in an artificial environment, usually a laboratory. In vitro testing includes checking blood for signs of infections, or urine for the presence of glucose.
Nowadays, in vitro diagnostics (IVDs) provide much more than simple assays conducted in test tubes and examining glass dishes under microscopes. IVDs are used in large-scale population screening, such as for cervical cancer, as well as for predicting whether a specific medicine or treatment will work on a patient. Patients with diabetes use IVDs regularly to monitor their blood glucose. They are also used to make or confirm a medical diagnosis, from confirming a pregnancy to checking for infectious diseases such as hepatitis or HIV.
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Disease Diagnosis is the process of determining which disease or condition explains a person's symptoms and signs. The tests can diagnose the disease in both symptomatic patients and people who show no signs of the disease. It is important to diagnose Wilson disease as early as possible, since severe liver damage can occur before there are any signs of the disease.
Health-care professionals use symptoms and signs as clues that can help determine the most likely diagnosis when illness is present. Symptoms and signs are also used to compose a listing of the possible diagnoses. This listing is referred to as the differential diagnosis. The differential diagnosis is the basis from which initial tests are ordered to narrow the possible diagnostic options and choose initial treatments.
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Diagnosis and treatment can prevent complications and reduce mortality. Molecular diagnostic techniques for viral testing have experimented a rapid development during the last years. The industrialisation of molecular biology assay tools has made it practical to use them in clinics.
Molecular diagnostics provides the necessary underpinnings for any successful application of gene therapy or biologic response modifiers. It offers a great tool for assessing disease prognosis and therapy response and detecting minimal residual disease.
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The molecular diagnostics market is categorized on the basis of application, technology, end user, product, and geography. On the basis of application, infectious diseases were the leading market segment, in 2013. Under this segment the CT/NG sub-segment contributed to the maximum share of the market.
The global molecular diagnostics market is segmented on the basis of application, technology, end user, product, and geography. Based on application, the market is further segmented into infectious diseases, oncology, genetics, blood screening, microbiology, and others.
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Biomarkers are likely to be important in the study of Alzheimer disease (AD) for a variety of reasons. A clinical diagnosis of Alzheimer disease is inaccurate even among experienced investigators in about 10% to 15% of cases, and biomarkers might improve the accuracy of diagnosis.
Biomarkers are the measures used to perform a clinical assessment such as blood pressure or cholesterol level and are used to monitor and predict health states in individuals or across populations so that appropriate therapeutic intervention can be planned.
Biomarkers are used to predict serious illnesses such as diabetes and cardiovascular disease. Each individual biomarker indicates whether there is a disease or health state and can be combined to provide a detailed picture of how healthy a person is and whether or not a diagnosis needs to be made.
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Molecular diagnostics is a technique used to analyse biological markers in the genome and proteome the individual's genetic code and how their cells express their genes as proteins by applying molecular biology to medical testing. The technique is used to diagnose and monitor diseases.
An ideal biomarker has certain characteristics that make it appropriate for checking a particular disease condition. Ideally, an ideal marker should have the following features:
Safe and easy to measure
Cost efficient to follow up
Modifiable with treatment
Consistent across gender and ethnic groups
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Journal of Cancer Science & Therapy, Journal of Cancer Biomarkers, The Journal of Molecular Diagnostics, Journal of Molecular and Genetic Medicine, Clinical Toxicology: Open Access, Molecular Diagnosis of Genetic Diseases, Medical Toxicology and Clinical Forensic Medicine, Clinical Genetics & Molecular Biology, Brazilian Journal of Genetics.
Journal of Molecular Biomarkers & Diagnosis is associated with our international conference "6th International Conference on Biomarkers & Clinical Research" (Biomarkers-2015) during August 31-September 02, 2015 Toronto, Canada with a thematic blend of “Lab to Industry as Biosignatures to Therapeutic Discovery”. We are particularly interested in research area Biomarker, genetic marker, screening, dna-profiling, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, biomarker toxicology.
*Unofficial 2015 Journal Impact Factor was established by dividing the number of articles published in 2013 and 2014 with the number of times they are cited in 2015 based on Google search and the Scholar Citation Index database. If 'X' is the total number of articles published in 2013 and 2014, and 'Y' is the number of times these articles were cited in indexed journals during 2015 then, impact factor = Y/X