RNA therapy for polyglutamine neurodegenerative diseases

RNA-based approaches represent promising therapeutic strategies for polyglutamine diseases, offering the potential to suppress gene expression in a sequence-specific manner at the transcriptional and post-transcriptional levels.

Microbubble Contrast Imaging of the Cardiovascular System of the Chick Embyro

Microbubble contrast ultrasound imaging in the chick embryo greatly expands the ability to study cardiovascular development. Also, the two natural embryonic A-V shunts provide an excellent model to study the bioeffects of microbubbles in the arterial system.

Imaging of the placenta with pathologic correlation

Imaging of the placenta can have a profound impact on patient management, owing to the morbidity and mortality associated with various placental conditions.

3D and molecular analysis of the arterial pole of the developing heart

Labeling experiments in chicken and mouse embryos have revealed important roles for different cell lineages in the development of the cardiac arterial pole.

Glutamine in pathogenesis of acute hepatic encephalopathy

The current status of glutamine in the pathogenesis of HE, in generation of oxidative stress and alterations in signaling mechanisms, including activation of MAPKs NF-κB and also mechanisms contributing to astrocyte swelling are described.