"In 2013, there are other researches on rabbits for diseased prions (PrPSc). Wang et al. (2013) aimed to investigate âpotential mechanisms contributing to prion resistance or susceptibility by using the rabbit, a species unsusceptible to prion infection, as a model and investigated âthe expression level and distribution of LRP/LR (laminin receptor precursor or laminin receptor) in rabbit tissues by real-time polymerase chain reaction and by immunochemical analysis with a monoclonal anti-67 kDa LR antibody âand at last their findings confirmed the prion resistance in rabbits. Sweeting et al. (2013) produced X-ray structures of mutants in the β2-α2 loop and reported that the helixcapping motif in the β2-α2 loop modulates β-state misfolding in RaPrP, and still acknowledged ârabbit PrP, a resistant speciesâ.
(Recent Advances in the Immunity Research of Rabbits to Prion Diseases : Jiapu Zhang)
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Last date updated on April, 2024
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