Clinical Microbiology: Open Access

Bioinformatics study of a novel viral protein associated with cotton leaf curl disease

3^rd International Conference on Clinical Microbiology & Microbial Genomics

September 24-26, 2014 Valencia Convention Centre, Spain

Jamal Alruwaili

Accepted Abstracts: Clin Microbial

Abstract:

DNA β of Begomovirus encodes the βC1 protein that is necessary for inducing symptoms of cotton leaf curl disease in plants. The structure of βC1 is still unknown. DoBo and I-TASSER servers, followed by PROCHECK and VERIFY 3D servers, were used for structure prediction and evaluation of this 13 kDa protein comprising 118 amino acid residues. Sequence analysis was performed by PSI-BLAST. Clustal W2 was used for phylogenetic analysis of βC1. DOMAC server was used to find out the number of domains present in the protein. The most probable role of βC1 in causing cotton leaf curl disease (CLCuD) is the suppression of RNA silencing in the host plant cells which produces the symptoms of the disease in cotton plants.

Biography :

Jamal Alruwaili received his doctoral degree in Biochemistry in 2011 from the University of Portsmouth in UK. The topic of his dissertation was ?Serum Proteomic Analysis of Prostate Cancer Progression?. He has served at the King Faisal Specialist Hospital in Riyadh (Saudi Arabia) as a Scientist. He is presently working as the Vice Dean of the Faculty of Applied Medical Sciences at Northern Border University in Arar, Saudi Arabia. He has published more than twelve papers in international journals on topics as diverse as proteomics, protein structure, molecular docking and drug delivery.