Clinical Microbiology: Open Access

Design of a therapeutic vaccine against hepatitis B virus

3^rd International Conference on Clinical Microbiology & Microbial Genomics

September 24-26, 2014 Valencia Convention Centre, Spain

Nadeem A Kizilbash

Accepted Abstracts: Clin Microbial

Abstract:

Therapeutic vaccines treat a disease or condition by inducing or strengthening a pre-existing immune response. A chimeric protein comprising the core and surface regions of the hepatitis B virus (HBV) envelope protein was designed as a therapeutic vaccine. The premise was that if the HBV surface protein is fused with the core protein of the viral envelope, it can produce both cellular and humoral immune response. NNPREDICT and PSIPRED programs were used to predict the secondary structure elements of the protein. 3D-JIGSAW was used to predict the tertiary structure of the protein. The tertiary structure shows α-helices form a helical bundle domain and the β-strands form a separate domain. The provided data can be used to explain binding to antibodies found on the surface of B-cells, class II MHC molecules and T-cell receptors (TCR).

Biography :

Nadeem A Kizilbash received a Master?s degree in Chemistry from Washington University, USA in 1996 and was awarded the Doctoral degree in Biophysics from Boston University, USA in 2003. He is currently serving as an Assistant Professor in the Faculty of Medicine & Applied Medical Sciences, Northern Border University, Saudi Arabia. He is the author of a monograph on fatty acid binding proteins and has published more than 16 papers in international journals. He is also serving on the editorial boards of 3 professional journals.