Journal of Analytical & Bioanalytical Techniques
Open Access

Abstract

Hollow fiber mediated liquid phase microextraction (HF-LPME) has demonstrated great potential in broad application areas such as pharmaceuticals, food and environmental industry. Specifically, its unique advantages of small sample requirements and relative easiness of operation enable it to be widely accepted by analytical chemists. Several new technologies based on this new technique for pharmaceutical applications including physical characterization, protein binding and quantitation are being developed. Due to its miniaturized structure, it is suitable for characterizing a large number of compounds by measuring their physical properties, such as log D and permeability. It is also shown that HF-LPME can be used for determining protein binding. Further, this technology has been applied to the determination of various pharmaceutical compounds in various complex matrixes including herb medicine and plasma. With the recent development in new HF-LPME device, it is feasible to conduct the aforementioned assays in high throughput format.

Biography

James J Bao had his PhD degree from Purdue University and is a Professor at Tianjin University now. His research interests include analytical method development for pharmaceutical analysis as well as new technology development. He has published more than 60 papers in reputed journals and has been serving as an editorial board member of several journals.