Journal of Pharmaceutical Care & Health Systems
Open Access

Drug design of diphenyl α-aminoalkylphosphonates as prostate-specific antigen antagonists

Global Pharma Summit

August 10-12, 2015 Philadelphia, USA

Hai-Feng Ji1, Arben Kojtari1, Vishal Shah1, Jacob S Babinec1 and Catherine Yang2

ScientificTracks Abstracts-Workshop: J Pharma Care Health Sys

Abstract :

We report that diphenyl α-aminoalkylphosphonate ester derivatives act as potent inhibitors of PSA, a likely protease responsible for the advancement of prostate tumor progression. The new lead compound R/S-diphenyl[N-benzyloxycarbonylamino (4-carbamoylphenyl) methyl]phosphonate showed a potent inhibitor of PSA activity with IC50= 250 nM. The study introduces novel aminoalkylphosphonates as a potential drug candidate for targeting PSA.

Biography :

Hai-Feng Ji is a Professor in the Department of Chemistry in the College of Arts and Sciences at Drexel University. His current research interests include micromechanical sensors for biological and environmental applications, nanopillars for energy applications, cancer detection and treatment, etc. He has published more than 130 peerreviewed journal publications.