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Helicobacter pylori promotes angiogenesis in gastric cancer cells depending on cyclooxygenase-2-mediated vascular endothelial growth factor via p38MAPK/ATF-2 pathway
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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Helicobacter pylori promotes angiogenesis in gastric cancer cells depending on cyclooxygenase-2-mediated vascular endothelial growth factor via p38MAPK/ATF-2 pathway


International Conference & Exhibition on Cancer Science & Therapy

15-17 August 2011 Las Vegas, USA

Qi Li

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Angiogenesis, the growth of new blood vessels, is closely related with the incidence and development of gastric cancer, but the pathogenesis of angiogenesis is still unknown in Helicobacter pylori ( H. pylori ) -induced gastric cancer. Previously, we reported that H. pylori could increase the expression of COX-2 via p38MAPK in vitro. In this study, we established a mice model of H. pylori infection to define the exact role of H. pylori infection in gastric carcinogenesis. Microvessel density (MVD) and Vascular endothelial growth factor (VEGF) mRNA expression in gastric mucosa were significantly higher in H. pylori infected mice than that in untreated mice after 72 weeks. Further analysis revealed that H. pylori infection induced VEGF through COX- 2 gene by the activation of p38MAPK. Thus, inhibition of either COX-2 or p38MAPK suppressed H. pylori infection induced VEGF at mRNA and protein level. In conclusion, our study has provided the first direct evidence that Helicobacter pylori induces C57BL/6 mice gastric adenocarcinoma and enhances VEGF expression via p38MAPK /COX-2 pathway.

Biography :

Qi Li has completed his Ph.D and MD.at Shanghai University of Traditional Chinese Medicine and postdoctoral studies from Cornell University. He is the director of Laboratorial Center and the chief of Research Branch at Putuo Hospital in Shanghai. He has published more than 50 papers in reputed journals, including 5 papers in SCI, and serving as an editorial board member of Tumor, Shanghai Traditional Chinese Medicine, and so on.

Google Scholar citation report
Citations: 3968

Cancer Science & Therapy received 3968 citations as per Google Scholar report

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