Hepatocellular carcinoma: Cytological findings

2^nd International Conference on Cytopathology & Histopathology

August 10-12, 2016 Las Vegas, USA

Maral Mokhtari, Perikala Vijayananda Kumar and Mohsen Reza Mansoorian

Shiraz University of Medical Sciences, Iran

Scientific Tracks Abstracts: J Cytol Histol

Abstract :

The occurrence of hepatocellular carcinoma is rising especially in areas with high incidence of viral hepatitis. Fine needle aspiration is a safe, cost effective and accurate method for diagnosis of liver space occupying lesions. In this study we report our experience in cytology of HCC. 58 patients (20 female and 38 male), histologically documented cases of hepatocellular carcinoma were studied retrospectively. 25 patients were cirrhotic. The frequency of viral hepatitis was 40% (30% HBV and 10% HCV). The smears were hyper-cellular consisting of two and three-dimensional clusters of round cells with centrally located nuclei in 58, 100% of cases. Atypical bare nuclei were frequently noted (49, 84% patients). Prominent nucleoli (25, 43% patients), endothelial cell rapping clusters of hepatocytes (40, 68% cases), transgressing vessels (38, 65% patients) intra-cytoplasmic bile (42, 72% patients), intranuclear pseudo inclusions (22, 37% patients) and hepatitic rosettes enclosing extracellular bile plugs (20, 34% cases) were observed. Tumor giant cells (31, 53% cases), tad pole-like cells (5, 8% cases) and Reed-Stenberg-like cells (1, 1.7% patient) were also seen. Some smears showed clusters of hepatocytes with clear cytoplasm and some of them showed micro-vesicular fatty change in 12, 20% patients. In conclusion, using different cytologic criteria, hepatocellular may reliably be differentiated from its mimickers. Besides other previously defined cytological features, Reed-Stenberg-like cells can be seen in hepatocellular carcinoma.

Biography :

Maral Mokhtari has completed her Pathology Specialty in Shiraz University of Medical Sciences. She is the Lab Director of Shahid Faghihi Hospital. She has published more than 25 papers in reputed journals.

Email: Maral_mokhtari@yahoo.com