Inhibitors of Hedgehog signaling pathway from Asclepiadaceae

International Conference and Exhibition on Marine Drugs and Natural Products

July 25-27, 2016 Melbourne, Australia

Xiaoyu Li

Zhejiang Academy of Medical Sciences, China

Posters & Accepted Abstracts: J Pharmacogn Nat Prod

Abstract :

Since activation of the Hedgehog signaling pathway is implicated in several types of human cancers, inhibitors of this pathway could be promising anticancer agents. C-21 steroids from Asclepiadaceae have antitumor effect. Studies of cell toxicity, gene chip and dual luciferase report gene found that C21 steroids could inhibit the activity of Hedgehog signaling pathway, suggesting that the inhibitory activity against tumor cell may be associated with inhibitory activity against Hedgehog signaling pathway. In order to establish the relationship between chemical structure of C-21 steroids from Asclepiadaceae and the anticancer activities and to elucidate the mechanism of the anticancer activities, chemical studies on the CHCl3/EtOAc soluble extract from more than ten plants were undertaken, leading to about eighty C-21 steroids, and their activities of inhibition of Hedgehog signaling pathway were tested in vitro. This study aims at finding new Hedgehog signaling pathway inhibitors as candidates for targeting antitumor drugs.

Biography :

Xiaoyu Li has completed his PhD from Zhejiang University department of Chemistry. He is the Professor of Institute of Materia Medica, Zhejiang Academy of Medical Sciences. He has published more than 20 papers in reputed journals.

Email: 13095710413@wo.com.cn