MYC/BCL2 double hit high grade B-cell lymphoma
5th World Hematologists Congress
August 18-19, 2016 London, UK

Shaoying Li

University of Texas MD Anderson Cancer Center, USA

Scientific Tracks Abstracts: J Blood Disord Transfus

Abstract:

Double-hit lymphoma (DHL) has been defined by 2008 WHO as a B-cell lymphoma with MYC/8q24 rearrangement in combination with a translocation involving another gene such as BCL2 or BCL6. The most common form of DHL has translocations involving MYC and BCL2, also known as MYC/BCL2 DHL. In the past few years, numerous case series of MYC/BCL2 DHL have been reported in the literature. Most cases of MYC/BCL2 DHL morphologically resemble diffuse large B-cell lymphoma (DLBCL) or high grade B-cell lymphoma, not otherwise specified (previous name in 2008 WHO: B-cell lymphoma, unclassifiable with features intermediate between DLBCL and Burkitt lymphoma). These tumors have a germinal center B-cell immunophenotype but an aggressive clinical course characterized by a high proliferation rate, advanced-stage disease, extranodal involvement, high International Prognostic Index score and high serum lactate dehydrogenase levels. All tumors have a complex karyotype. Despite a variety of therapeutic approaches that have been used to date, patients with DHL have a poor prognosis. Here we will discuss the clinicopathologic, immunophenotypic, cytogenetic and prognostic features of MYC/BCL2 DHL and some remaining issues.

Biography :

Shaoying Li has received her MD from Beijing Medical University (Current name: Peking University Health Science Center). She is an Assistant Professor in the Department of Hematopathology at the University of Texas MD Anderson Cancer Center. She is board certified in Anatomic Pathology, Clinical Pathology and Hematology. In addition to clinical responsibilities on lymphoma, leukemia and flow cytometry services, she has been actively participating in multiple research projects in lymphoma and leukemia, which has led to 50 research papers and multiple book chapters. She also serves as Member of Editorial Boards and ad hoc Reviewer for multiple journals. Her major research interests include molecular cytogenetic risk stratification of DLBCL with a focus on “double hit” lymphoma and clinicopathologic and molecular study of mantle cell lymphoma.

Email: SLi6@mdanderson.org