Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us +44-3308187254

GET THE APP

Novel Chalcone Derivatives: Synthesis, QSAR Studies And Evaluation Of Their Anti-prostate Cancer Activities And Cathepsin B Inhibition | 37446

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Novel chalcone derivatives: Synthesis, QSAR studies and evaluation of their anti-prostate cancer activities and cathepsin B inhibition

Pharma Middle East

Dalia Hussein Soliman1, 2

1Al-Azhar University, Egypt 2Egyptian Russian University, Egypt

ScientificTracks Abstracts: Clin Pharmacol Biopharm

DOI: 10.4172/2167-065X.C1.013

Abstract
Prostate cancer is one of the most commonly diagnosed cancers in men, and the second leading cause of cancer deaths in the European Union and United States of America. The high mortality rate is mainly attributed to the invasiveness and metastasis of advanced prostate cancer. Cathepsin B is a cysteine protease found mainly in the lysosomes. The increased expression and secretion of cathepsin B have been shown to be involved in migration and invasion of numerous human and experimental tumors. Therefore, the use of cathepsin B inhibitors reduces both tumor cell motility and invasiveness in vitro. In the present study a series of novel chalcones were prepared and studied for both their anti-prostate and cathepsin B inhibition. Furthermore, a QSAR study was carried out where models were successfully built from which the physicochemical parameters were correlated to the activity.
Biography

Dalia Hussein Soliman has completed her PhD from AL-Azhar University and Postdoctoral studies from the same University in addition to Ain-Shams University. She is currently working as an Associate Professor at Pharmaceutical Chemistry Department at the Egyptian Russian University. She has published more than 12 papers in reputed journals.

Email: odihss3@gmail.com

Top