Journal of Cell Science & Therapy
Open Access

Potential therapies with adult stem/progenitor cells from bone marrow (MSCs) and the proteins they produce in response to injuries from injured tissues

International Conference & Exhibition on Cell Science & Stem Cell Research

29 Nov - 1 Dec 2011 Philadelphia Airport Marriott, USA

Darwin J. Prockop

Keynote: J Cell Sci Ther

Abstract :

T herapeutic benefi ts in a number of models for human disease have been reported with administration of the adult stem/ progenitor cells from bone marrow referred to as mesenchymal stem cells or mesenchymal stromal cells (MSCs). We observed that intravenously administered MSCs improved myocardial infarction in mice by being trapped in lung where they created microemboli that activated the cells to synthesize TSG-6, and the TSG-6 reduced the excessive infl ammatory response that damaged cardiomyocytes (Lee et al. Cell Stem Cell 2009). We also observed that intraocular administration of TSG-6 reduced the excessi ve infl ammatory response that damaged the cornea in a rodent model for chemical injury of the eye (Oh et al. PNAS 2010). In parallel experiments we observed that retinal degeneration was decreased in a rat model for retinitis pigmentosa by intravitreal adminis tration of STC-1 (Roddy et al. ARVO abstract, 2011), an anti-apoptotic protein produced by hMSCs in response to signals from apoptotic cells (Block et al. Stem Cells 2009). Th e results indicate that some but not all the therapeutic benefi ts observed with administration of MSCs in disease models can be explained by the cells being activated to express either TSG-6 or STC-1. Supported in part by N IH grants HL 073755 , PO1 RR 17447, and 1R21EY020962

Biography :

Darwin J Prockop was born in August 31,1929; Palmerton, PA and educational pro fi le includes S. S. Palmer High School, 1947 Haverford College, A.B. (Philosophy and Pre-Medical), 1951 Brasenose College, Oxford University, M.A. (Animal Physiology), 1953 University of Pennsylvania, M.D., 1956 George Washington University, Ph.D. (Biochemistry), 1961 And his fellowships: as includes New York Hospital-Cornell Medical Center, Intern-in-Medicine, 1956-1957 MCP Hahnemann University (formerly Allegheny University of the Health Sciences), ? Director, Center for Gene Therapy, 1996-2000 ? Tulane University Medical Center, Director, Center for Gene Therapy, 2000- And he is editorial board member of so many national and international reputed journals