Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

The recent arrival of the target specific oral anticoagulants (TSOACS) offers potential advantages in the field of anticoagulation. However, there are no rapid and accurate and routinely available laboratory assays to evaluate their contribution to clinical bleeding. With the expanding clinical indications for the TSOACS, and the arrival of newer reversal agents on the market, the Emergency Clinician will need to be familiar with drug specifics as well as methods for anticoagulation reversal. This lecture offers a summary of the literature of animal studies and human trials and will present some practical strategies for the approach to the patient taking TSOACs and the management of bleeding in these specific cases.

Biography

Kristen E Nordenholz, MD, MSc, is an Associate Professor of Emergency Medicine at the University of Colorado, School of Medicine and has been practicing clinical Emergency Medicine for the past 22 years. She has a strong clinical and research interest in the diagnosis and treatment of venous thromboembolism and the use of anticoagulation and its complications. The arrival of the new target specific anticoagulants has changed the landscape of the emergency management of bleeding complications in patients who are taking these medications. As such, Emergency Medicine as a specialty, including her as an Emergency Physician, is at the center of an important collaboration with pharmacists and numerous other specialists as to the best course of management in these cases.