Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Background: Intravenous (IV) paracetamol has a significant opioid-sparing effect. We investigated the effect of paracetamol infusion on sevoflurane consumption during entropy monitored general anesthesia. Methods: Sixty-two ASA I and II patients undergoing thyroidectomy under general anesthesia were included in a prospective, randomized, double-blind and placebo controlled study. The patients were randomized to receive a slow infusion of either 1g paracetamol (paracetamol group, n=31) or saline (control group, n=31) just before induction of anesthesia. Sevoflurane concentration was titrated to keep the state entropy value between 40 and 50. End-tidal sevoflurane concentration, sevoflurane consumption, recovery characteristics, time to first analgesic request and meperidine consumption during the first 6 postoperative hours were recorded. Results: The mean?SD estimated sevoflurane consumption was significantly lower in the paracetamol treated patients (36.2?15 vs 44.9?13.9ml, in the control group; p=0.021). Patients receiving paracetamol had a faster post-anesthetic recovery profile (extubation time, time to eye opening to command and time to state name and mention his/her home address) than the other group (p<0.05). Mean?SD time to first analgesic request was significantly prolonged in paracetamol group compared to control group (48.4?14.0 vs 40.7?11.5min, respectively; p=0.021). Meperidine consumption was higher in control group than in paracetamol group (28.7?10.2 vs 23.1?9.0mg, respectively; p=0.025). Conclusion: Preoperative IV paracetamol infusion improved consumption and emergence from entropy monitored sevoflurane anesthesia with enhancement of the early postoperative analgesia.

Biography

Walid M Abdelmageed is an Assistant Professor of anesthesia and intensive care in faculty of medicine, Ain shams University, Cairo, Egypt. He received his MD degree from Ain shams University, Cairo in 2003. He was part of the anesthesia team of the first liver transplantation from live donor done in Egypt in 2005. He has several publications. He is especially interest in intensive and critical care.