Drug Designing: Open Access
Open Access

Preparation and evaluation of mucoadhesive Resveratrol microbeads using thiolated alginate for intrapocket delivery

International Conference and Expo on Drug Discovery & Designing

August 11-13, 2015 Frankfurt, Germany

Abeer Ahmed Kassem1, 2, Ragwa Mohamed Farid3, Doaa Ahmed Elsayed Issa4, 2, Doaa Said Khalil5, Mona YehiaAbd-El-Razzak6, Hussein Ibrahim Saudi6, Heba Mohamed Eltokhey6 and EnasArafa El-zamarany6

Posters-Accepted Abstracts: Drug Des

Abstract :

Resveratrol (Res), a polyphenolic phytoalexin, had shown a promising therapeutic efficacy towards treatment of periodontal
disease in vitro. This work aims to develop Res microbeads with strong mucoadhesion using thiolated alginate (TA) for
local treatment of periodontal pockets. TA was synthesized by conjugating sodium alginate (A) with thioglycolic acid. Product
was evaluated by IR and DSC. Both A and A: TA Res micro beads with different ratios were prepared by ionotropic gelation
method. Formulations were evaluated regarding their entrapment efficiency (%EE), swelling index (SI), in vitro drug release and
kinetics. Selected formula was examined for its mucoadhesion by ex vivo wash-off method, surface morphology using scanning
electron microscope (SEM) and stability against light. Clinical evaluation is running. Formation of TA was confirmed. % EE for
all formulations ranged from 83.72 to 104.54%. Results revealed a significant lower SI for TA rich formulation (A/TA 1:1) along
with slower release rate and zero-order kinetics, in addition to powerful mucoadhesion; 26% remaining of microbeads after 1 h,
compared to 2% for A microbeads. SEM micrographs showed a rough surface with drug precipitation. The formula maintained
its %EE after 5 h exposure to direct sunlight. A/TA 1:1 mucoadhesive Res microbeads could be exploited as a prolonged drug
release devices for intrapocket application.

Biography :

Abeer Ahmed Kassem has completed her (2008) from Faculty of Pharmacy, Alexandria University, Egypt. Currently she is an Assistant Professor in Faculty of Pharmacy,
Princess Nourahbint Abdulrahman University, Saudi Arabia. She has published about 8 papers in reputed journals and two books. She served as a reviewer in reputed
journals, e.g. Int. J. Pharm. and Drug Delivery. She taught pharmacy undergraduate students (2008 till now), for different courses, e.g. Solid Dosage Forms, Hospital
Pharmacy and Biopharmaceutics. She was the Manager of the quality assurance unit, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria,
Egypt (2008-2010).