Journal of Pharmacovigilance

Synthesis of novel chromene derivatives of expected antitumor activity

Conference Series LLC Joint International Event on 7^th Pharmacovigilance & Pharmaceutical Industry

August 22-24, 2016 Vienna, Austria

Manal M Kandeel, Aliaa M Kamal, Eman K A Abdelall and Heba A H Elshemy

Future University, Egypt
Cairo University, Egypt
Beni-Suef University, Egypt

Posters & Accepted Abstracts: J Pharmacovigil

Abstract:

Inhibition of tubulin polymerization is one of the important tactics in cancer therapy. Since 4-aryl-4-H-chromene derivatives are found to be microtubule-binding agents via interfering with tubulin polymerization so we decide to concentrate our exploration efforts on the combination of this nucleus with 5-, 6-, and/or 7-memebered heterocyclic moieties in a novel series of compounds to explore the effect that might result from this combination. Ten novel compounds were selected for anticancer screening assay against MCF-7 breast cancer cell line in comparison to colchicine as positive control and most of them showed excellent activity.

Biography :

Manal M Kandeel is Professor of Pharmaceutical Organic Chemistry at the Faculty of Pharmacy, Cairo University and Vice Dean for Postgraduate Studies and Research Affairs, at the Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Egypt. Formerly, she held several positions including Vice Dean of Postgraduate Studies and Research Affairs and Community Service and Environment at the Faculty of Pharmacy, Cairo University. Her primary research area of interest is design, synthesis, structure elucidation and development of anticonvulsant, antimicrobial and anticancer agents. She published numerous articles in various national and international journals.

Email: manal.kandeel@fue.edu.eg