ISSN: 2157-7552
Journal of Tissue Science & Engineering
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Remembering Pioneers in Patient Treatments

David A Prentice*
Indiana State University, Family Research Council, Washington, USA
Corresponding Author : David A Prentice, Professor
Indiana State University, Family Research Council
Washington, USA
Tel: 202-637-4616
Fax: 202-393- 2134
E-mail: dap@FRC.ORG
Received October 19, 2012; Accepted October 22, 2012; Published October 24, 2012
Citation: Prentice DA (2012) Remembering Pioneers in Patient Treatments. J Tissue Sci Eng 3:e119. doi: 10.4172/2157-7552.1000e119
Copyright: © 2012 Prentice DA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Tissue Science & Engineering

It was very heartening to see Dr. Shinya Yamanaka recognized with the 2012 Nobel Prize for Physiology or Medicine [1], for his work in development of induced pluripotent stem cells (iPS cells), an ethical route to create pluripotent stem cells [2]. Even more heartening was Dr. Yamanaka’s rationale for creation of iPS cells, and his ultimate aim, the patients:
“So my goal, all my life is to bring this technology, stem cell technology to the bedside, to patients, to clinics” [3].
We sometimes lose sight of that ultimate goal, the real reason behind our exciting laboratory investigations, late nights in the lab, grant submissions, published papers, and talks at meetings. That is why it is so important to celebrate these pioneers of basic science and of patient treatments. It is also important to remember practitioners who have labored in the laboratory and in the clinic, with that patientcentered goal in mind.
The last couple of years have seen the passing of several patientcentered pioneers in the field of regenerative medicine. Perhaps, most noticed was the death in January 2011 of Canadian scientist Ernest McCulloch. The late Dr. McCulloch and his colleague James Till were pioneers in bone marrow transplant and bone marrow adult stem cells. Their early work with mice in the 1960′s provided the first evidence for the existence of bone marrow adult stem cells [4], and laid the theoretical groundwork for applications in bone marrow and adult stem cell transplantation [5].
Another early pioneer whose passing went relatively unnoticed at the time was French scientist Dr. Georges Mathe, who died in October 2010 [6]. In 1958, he used donor bone marrow transplants to save several physicists, accidentally exposed to high doses of radiation [7], and published one of the first successful donor bone marrow transplants for a patient with acute lymphoblastic leukemia, in 1963 [8].
In 2012, we lost two more pioneers who were dedicated to pushing the frontiers of patient treatment using adult stem cells. The passing of these two patient-centered pioneers should not go unnoticed, nor should they and their accomplishments be forgotten.
Dr. Julio Voltarelli of Brazil died in March of 2012. Dr. Voltarelli was a Professor at the Ribeirão Preto School of Medicine at the University of São Paulo, Brazil. He developed a highly ranked bone marrow and stem cell transplantation program, and initiated research efforts for adult stem cell transplants directed at autoimmune diseases, including Type I diabetes. The efforts bore fruit, resulting in at least 20 Type I diabetes patients becoming insulin free, after their treatment. The first, groundbreaking results were published in 2007 [9]. The research team published a follow-up paper in 2009 that included additional patients, noting that at that time, their technique utilizing the patient’s own adult stem cells was “the only treatment capable of reversing type 1 DM in humans” [10].
Dr. Carlos Lima of Portugal passed unexpectedly in June, 2012. Dr. Lima was a pioneer in the use of nasal mucosal tissue containing adult stem cells for the treatment of spinal cord injury. He built a skilled team at the Hospital de Egas Moniz in Lisbon, Portugal, and included international collaborators to bring the best neurological expertise, to bear on the problem of using regenerative medicine techniques for treatment of spinal cord injuries. The team’s first publication in 2006 provided information on the first few patients to undergo the technique and experience clinical improvement [11]. Their 2010 paper showed more extensive data, with significant improvement in paraplegic and quadriplegic spinal cord injury patients, even when treatment was begun years after the injury. They observed that 12 of 13 AIS A patients improved in AIS grade, and all of the patients regained some muscle movement in their legs [12].
As we celebrate the accomplishments of these pioneers, let us remember them and their goal—to keep the focus on the patients.

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 11269
  • [From(publication date):
    December-2012 - Oct 25, 2016]
  • Breakdown by view type
  • HTML page views : 7539
  • PDF downloads :3730

Post your comment

captcha   Reload  Can't read the image? click here to refresh

OMICS International Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
OMICS International Conferences 2016-17
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2016 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version