Rheumatology

Antirheumatic Therapy

Rheumatic diseases particularly rheumatoid arthritis and systemic lupus erythematosus shows an immune-mediated pathogenesis including proliferation of immunocompetent cells, an application was soon found for immunosuppressive drugs in their treatment. Immunoactive drugs such as mycophenolate mofetil, dapson and thalidomide are in use

Alignment Changes in Total Knee Arthroplasty

Mechanical axis restoration is a primary goal of total knee arthroplasty. Incomplete asymmetrical component seating through intended or unintended alterations in surgical technique, changes the component alignment and thus, the overall mechanical axis

Symptomatic Osteoarthritis of the Knee

Obesity leads to osteoarthritis remains unknown, but is likely to be due to a combination of mechanical, humoral and genetic factors. Weight loss has clear medical benefits for the obese patient and seems to be a logical way of relieving joint pain associated with degenerative arthritis

Gene delivery to Bone: an Experimental Tool

Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic strategy. Local delivery of osteogenic transgenes, particularly those encoding bone morphogenetic proteins, has shown applications where it is necessary to regenerate bone

Inflammatory Rheumatic Disorders

Inflammatory joint diseases such as rheumatoid arthritis as well as other rheumatic conditions comprise a heterogeneous group of joint disorders that are all associated with extra-articular side effects, including bone loss and fractures. The pathogenesis of osteoporosis in these patients is multifactorial

Rheumatoid Hand Deformities: Strengthening Exercises

Exercises are used to reduce rheumatoid hand deformities and to increase hand strength. The strengthening exercises for individuals with RA hand deformity are beneficial to improve handgrip and pinch strengths as well as functionality.

Phosphate homeostasis: Bone health

Phosphate is one of the most abundant mineral in the body. Phosphatonins are the regulators of phosphate homeostasis. Maintenance of phosphate levels within a narrow range is important for many biological processes, skeletal development and bone integrity.

Risks Associated with Surgery in the Elderly Obese

Obesity increases the risks and costs of hip and knee surgery. Better approaches are needed to reduce these risks. Medicare should consider incorporating incremental costs of caring for obese patients into payment policy and include obesity in severity adjustment models.

Patellofemoral Pain in Dancers

The present study was to determine the association between joint range of motion (ROM) and patellofemoral pain syndrome (PFPS) in young female dancers. When making an association between joint ROM and injuries, ROM at neighboring joints also should be considered.