Journal of Blood Disorders & Transfusion

ISSN: 2155-9864

Journal of Blood Disorders & Transfusion

Antiphospholide Antibody Syndrome

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Antiphospholide Antibody Syndrome

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Antiphospholipid syndrome (APS) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. Characteristic laboratory abnormalities in APS include persistently elevated levels of antibodies directed against membrane anionic phospholipids (ie, anticardiolipin [aCL] antibody, antiphosphatidylserine) or their associated plasma proteins, predominantly beta-2 glycoprotein I (apolipoprotein H); or evidence of a circulating anticoagulant.

Antiphospholipid antibody syndrome (APLAS) is a condition characterized by the presence of antiphospholipid (aPL) antibodies in the blood cells associated with recurrent arterial or venous thrombosis, recurrent spontaneous abortions, and thrombocytopenia. Diagnosis of the antiphospholipid syndrome (APS) is based on clinical and biological criteria including the persistent presence of antiphospholipid antibodies and thrombotic events or pregnancy morbidity. Heparins relayed by vitamin K antagonists (VKA) are the gold standard treatment for thrombosis.

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Antiphospholide Antibody Syndrome

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