Journal of Brain Tumors & Neurooncology

Meningeal carcinomatosis

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Meningeal carcinomatosis

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Meningeal carcinomatosis is a condition in which a solid tumor diffusely spreads to the leptomeninges. Lung tumors, breast tumors, and malignant melanoma comprise the majority of solid tumors spreading to the leptomeninges. The most common cancers to involve the leptomeninges are breast cancer, lung cancer. Patients present with signs and symptoms from injury to nerves that traverse the subarachnoid space, direct tumour invasion into the brain or spinal cord, alterations in blood supply to the nervous system, obstruction of normal cerebrospinal fluid (CSF) flow pathways, or general interference with brain function, and melanomas.

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Meningeal carcinomatosis

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