Transcriptomics: Open Access

ISSN: 2329-8936

Transcriptomics: Open Access

Transcriptional Regulation

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Transcriptional Regulation

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 In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is transcribed. It is estimated that the human genome encodes approximately 25,000 genes, about the same number as that for corn and nearly twice as many as that for the common fruit fly. Even more interesting is the fact that those 25,000 genes are encoded in about 1.5% of the genome. So, what exactly does the other 98.5% of our DNA do? While many mysteries remain about what all of that extra sequence is for, we know that it does contain complex instructions that direct the intricate turning on and off of gene transcription.

Related Journals of Transcriptional Regulation

Transcriptomics, Gene Technology, Journal of Genetic Syndromes & Gene Therapy, Human Genetics & Embryology, Gene, Gene Expression, Gene Expression Patterns, Genes and Genetic Systems, Genes and Genomics

 

Transcriptional Regulation

Expert PPTs

Speaker PPTs

  • Masayuki Fukata
    Innate immune regulation of T-helper (Th) cell homeostasis in the intestine
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  • Cormac G M Gahan
    Bacterial bile salt hydrolase in the regulation of host lipid metabolism and circadian rhythm: A role in probiotic function?
    PPT Version | PDF Version
  • Osama O. Ibrahim
    Chemicals structure, properties, regulations and applications of non-nutritive-high intensity sweeteners
    | PDF Version
  • Ilana Kolodkin-Gal
    Maintaining motile cells inside the biofilm through cell-to-cell signaling, transcription regulation and evolution
    PPT Version | PDF Version
  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Yousuke Nishio
    Metabolic control of the TCA cycle by the YdcI transcriptional regulator in Escherichia coli
    PPT Version | PDF Version
  • Steffi Baldini
    Regulation of hepatic Fatty Acid Synthase properties by O-GlcNAcylation in vivo and ex vivo
    PPT Version | PDF Version
  • Pi-Wan Cheng
    Disregulation of Golgi localization of glycosyltransferases alters mucin O-glycosylation and survival or metastatic properties of cancer cells
    PPT Version | PDF Version
  • Mirza Saqib Baig
    NOS1-derived nitric oxide promotes NF-kB stability and transcriptional activity by inhibiting suppressor of cytokine signaling (SOCS-1) in response to TLR4 activation
    PPT Version | PDF Version
  • Arghya Adhikary
    PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a
    PPT Version | PDF Version
  • Myron R Szewczuk
    Transcriptional factor Snail and MMP-9 signaling axis controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma
    PPT Version | PDF Version
  • Amin A Fadl
    Post-transcriptional modification of RNA: Effect on biology and virulence of Salmonella
    PPT Version | PDF Version
  • Mona Mohammed
    Key considerations of orphan products designation and registration regulation
    PPT Version | PDF Version
  • Wilhelm Engstrom
    Epigenetic regulation of the Igf2/H19 gene cluster - Prospects for novel therapeutic traits
    PPT Version | PDF Version
  • Kyoung-Jae Won
    Using nascent RNAs to study the transcriptional regulation in adipocytes
    PPT Version | PDF Version
  • Yajun Yi
    Meta-analysis of transcriptional profiles in cancer for prognosis prediction and metastatic gene identification
    PPT Version | PDF Version
  • Mohammad Hassan
    MicroRNA 23a~27a~24-2 cluster regulation of bone formation
    PPT Version | PDF Version
  • Gaylen Uhlich
    Production and regulation of functional amyloid curli fimbriae by Shiga toxin-producing Escherichia coli.
    PPT Version | PDF Version
  • Meg Mangin
    Clinical Evidence of Immune System Dysregulation Caused by Intracellular Infection
    PPT Version | PDF Version
  • Estibalitz Laresgoiti-Servitje
    ROLE OF microRNASAND CD4+ T CELLSUBSETS IN THE REGULATIONOF THEIMMUNE SYSTEMDURINGPREGNANCY
    PPT Version | PDF Version
  • Hussain Mustatab Wahedi
    Co-regulation of Sirt1 and Pin1 contributes to UV A/B-induced skin photo ageing
    | PDF Version
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