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Kyoung-Jae Won

Kyoung-Jae Won

University of Pennsylvania, USA

Title: Using nascent RNAs to study the transcriptional regulation in adipocytes

Biography

Kyoung-Jae Won has completed his Ph.D. University of Southampton, UK in 2006 and postdoctoral studies from University of Copenhagen, Denmark and University of California, San Diego. He is a research assistant professor of Genetics at the University of Pennsylvania. He has published more than 20 papers in reputed journals.

Abstract

Rosiglitazone (rosi) is an insulin sensitizing drug that functions as a ligand for PPAR and remodels the transcriptome of mature adipocytes. However, the direct effects of rosi on genomic transcription have not been evaluated. Here, using global run-on followed by deep sequencing (GRO-seq), we demonstrate that rosi has dramatic effects on RNA transcription in mature adipocytes.

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