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Biography

Mirette Hanna is about to accomplish her PhD studies in Experimental Medicine at Laval University. She is a Physician (medical degree obtained from Alexandria University) specialized in clinical pathology and blood banking. She has a Master degree in Clinical and Chemical Pathology from Ain Shams University. She has many papers and communications (around 10) in reputed journals and conferences.

Abstract

Chronic inflammation plays a role in breast carcinogenesis. Local inflammation would be manifested by increased expression of pro-inflammatory markers [interleukin-6 (IL-6) or tumor necrosis factor-α (TNF-α)] to anti-inflammatory marker [transforming growth factor-β (TGF-β)] in breast tissue. It was assessed if local inflammatory state in breast tissue would affect the mammographic density, a breast cancer risk factor, among 82 premenopausal and 82 postmenopausal breast cancer patients. For each patient, six cores of normal breast tissue, located at >1.0 cm from the tumor, were extracted from mastectomy blocks and used to build up tissue microarray (TMA) blocks. TMA cut sections were stained by immunohistochemistry and digitized. The protein expression levels of inflammatory markers were visually estimated (intensity and proportion of positive cells) in normal epithelium present on digitized stained TMA sections. Quick score was obtained by multiplying the intensity by the proportion of positive cells. The pro- to anti-inflammatory marker expression ratios (IL-6/TGF-β and TNF-α/TGF-β) were calculated in three categories based on the quick score; anti-inflammatory (pro-inflammatory markeranti-inflammatory marker). Mammographic density was evaluated by a computer-assisted method. Associations were assessed by multivariate generalized linear models. Pro-inflammatory state of TNF-α/TGF-β among premenopausal women and IL-6/TGF-β among postmenopausal women were associated with higher percent mammographic density compared to the anti-inflammatory or the neutral state (p=0.014 and p=0.005, respectively). Affecting the expression of inflammatory markers in breast tissue may provide attractive targets for future breast cancer preventive strategies

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