ISSN: 2161-038X
Reproductive System & Sexual Disorders: Current Research
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

"Taste" takes Control of "Testes": A New Trick for an Old Gene Family

Wei Li*
Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, 169 Changle West Road Xi’an 710032, China
Corresponding Author : Wei Li
Department of Human Anatomy
Histology and Embryology
Fourth Military Medical University
169 Changle West Road Xi’an 710032, China
Tel: 86-29-84774511
Received November 25, 2013; Accepted December 03, 2013; Published December 10, 2013
Citation: Li W (2013) “Taste” takes Control of “Testes”: A New Trick for an Old Gene Family. Reprod Syst Sex Disord 3:e111. doi:10.4172/2161-038X.1000e111
Copyright: © 2013 Li W. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Visit for more related articles at Reproductive System & Sexual Disorders: Current Research

The TAS1R taste receptors, best known as sugar and amino acid sensing in taste cells and in the gastrointestinal tract, are required for proper sperm formation, according to a very new study in mice. These extraoral “taste” molecules seem to directly participate in the sperm development and maturation, a process that normally occurs at the late stage of spermatogenesis.
Mice and humans each have three types of TAS1R receptors: TAS1R2+TAS1R3 form a sweet receptor, and TAS1R1+TAS1R3 form an umami receptor. TAS1R3 is the common subunit and may also serve as a low-affinity sweet receptor alone. The TAS1R receptors have also been implicated in male reproduction. In mice, for instance, T1R2 is expressed in the primary spermatocyte or spermatogonial cells, as revealed by a T1R2-LacZ knock-in mouse model. TAS1R1 is also found to be expressed in mouse spermatozoa and has been implicated in regulating basal Ca2+ and cAMP concentrations in spermatozoa.
To examine the function of TAS1R receptors more closely, Mosinger et al. first examined the expression pattern of Tas1r3 gene and its associated heterotrimeric G protein gustducin α-subunit Gnat3 gene in the male reproductive system using in situ hybridization [1]. They found that Gnat3 and Tas1r3 were both expressed in testis, with strong positive signals being detectable in the elongating and elongated spermatids. Of note, expression of these two genes appears to be specific to testes because they were not found in epithelial cells in epididymis, or in ovaries, although TAS1R1 expression in ovaries has been reported.
Further evidence for a direct role of TAS1R3 and GNAT3 in the modulation of sperm formation is provided by using a mouse model that expressed a humanized form of TAS1R3 susceptible to inhibition by the antilipid medication clofibrate. Sperm formation in animals without functional TAS1R3 and GNAT3 is significantly impaired, with malformed and immotile sperm. In addition, clofibrate inhibition of humanized TAS1R3 in the genetic background of TAS1R3−/−, GNAT3−/− doubly null mice led to inducible male sterility. Closer analysis revealed that TAS1R3 and GNAT3 may affect cAMP levels and Ca2+ signaling in spermatids, thus resulting in disruption of several critical pathways required for normal sperm development.
A number of natural and synthetic anti-sweet or sweet-modifying substances/ antagonists exist. The long-term biological effects of these compounds in humans are not well known, although some reports point to male infertility. To this end, this study suggests that inhibitors of human TAS1R3 together with nonspecific G protein inhibitors, or mutations in these genes, could result in infertility or sterility, which should shed light on some forms of idiopathic male infertility.

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 11213
  • [From(publication date):
    January-2014 - Oct 25, 2016]
  • Breakdown by view type
  • HTML page views : 7479
  • PDF downloads :3734

Post your comment

captcha   Reload  Can't read the image? click here to refresh

OMICS International Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
OMICS International Conferences 2016-17
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2016 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version